Evidence map›Paper›PMID 34943840›Full record

ArticleCells2021

Deficiency of Cathelicidin Attenuates High-Fat Diet Plus Alcohol-Induced Liver Injury through FGF21/Adiponectin Regulation.

Fengyuan Li, Jenny Chen, Yunhuan Liu, Zelin Gu, Mengwei Jiang, Lihua Zhang, Shao-Yu Chen, Zhongbin Deng, Craig J McClain, Wenke Feng

Open access · goldAbstract read
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Fengyuan LiDepartment of Medicine, University of Louisville, Louisville, KY 40202, USA.ORCID 0000-0003-1821-3357
Jenny ChenDepartment of Medicine, University of Louisville, Louisville, KY 40202, USA.
Yunhuan LiuDepartment of Medicine, University of Louisville, Louisville, KY 40202, USA.
Zelin GuDepartment of Medicine, University of Louisville, Louisville, KY 40202, USA.
Mengwei JiangDepartment of Medicine, University of Louisville, Louisville, KY 40202, USA.
Lihua ZhangDepartment of Medicine, University of Louisville, Louisville, KY 40202, USA.
Shao-Yu ChenDepartment of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40202, USA.
Zhongbin DengAlcohol Research Center, University of Louisville, Louisville, KY 40202, USA.
Craig J McClainDepartment of Medicine, University of Louisville, Louisville, KY 40202, USA.
Wenke FengDepartment of Medicine, University of Louisville, Louisville, KY 40202, USA.
University of Louisville · US

Funding

The Role of Nutrition in the Development/Progression of Alcohol-Induced Organ InjuryP50AA024337 · NIAAA · UNIVERSITY OF LOUISVILLE · PI CRAIG J. MCCLAIN · 2016 to 2026
$17.9M
Mechanisms of Probiotics in Alcoholic Liver DiseaseR01AA023190 · NIAAA · UNIVERSITY OF LOUISVILLE · PI FENG, WENKE · 2015 to 2024
$3.5M
CSN8 regulation of S1P-enriched extracellular vesicles to modulate NAFLD by gut-liver axisR01DK115406 · NIDDK · UNIVERSITY OF LOUISVILLE · PI DENG, ZHONG-BIN · 2018 to 2022
$2.0M
Role of exosomes in the coordinated migration of neural crest cells and placodes and ethanol-induced teratogenesisR01AA028435 · NIAAA · UNIVERSITY OF LOUISVILLE · PI CHEN, SHAO-YU · 2020 to 2024
$1.8M
Gut extracellular vesicles promote alcohol-induced liver injury via TLR4-regulated miRNAsR21AA025724 · NIAAA · UNIVERSITY OF LOUISVILLE · PI DENG, ZHONG-BIN · 2018 to 2019
$558k
Intestinal epithelial cells-derived exosomal miRNAs regulate liver inflammation in obesityR21AI128206 · NIAID · UNIVERSITY OF LOUISVILLE · PI DENG, ZHONG-BIN · 2017 to 2018
$424k
NIAAA NIH HHS P50 AA024337NIAAA NIH HHS R01 AA023190NIAAA NIH HHS R01 AA028435NIAAA NIH HHS R21 AA025724NIAID NIH HHS R21 AI128206NIDDK NIH HHS R01 DK115406
6 · The paper itself

Abstract

Alcohol consumption and obesity are known risk factors of steatohepatitis. Here, we report that the deficiency of CRAMP (cathelicidin-related antimicrobial peptide-gene name:

Indexed as

AdipocytesAdiponectinAdipose TissueAdipose Tissue, BrownAdipose Tissue, WhiteAnimalsCathelicidinsDiet, High-FatEthanolFatty AcidsFatty LiverFeeding BehaviorFibroblast Growth FactorsHypertrophyInflammationLipolysisAdiponectinCamp protein, mouseCathelicidinsEthanolFatty Acidsfibroblast growth factor 21Fibroblast Growth Factorsadipose lipolysiscathelicidinFGF21/adiponectinHFD plus alcoholneutrophil

Identifiers

PMID34943840
PMCPMC8699208
OpenAlexW3217587064

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.