Evidence map›Paper›PMID 34943806›Full record

ArticleCells2021

Glycation Interferes with the Expression of Sialyltransferases in Meningiomas.

Philipp Selke, Kaya Bork, Tao Zhang, Manfred Wuhrer, Christian Strauss, Rüdiger Horstkorte, Maximilian Scheer

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Philipp SelkeMedical Faculty, Institute for Physiological Chemistry, Martin-Luther-University Halle-Wittenberg, 06114 Halle (Saale), Germany.
Kaya BorkMedical Faculty, Institute for Physiological Chemistry, Martin-Luther-University Halle-Wittenberg, 06114 Halle (Saale), Germany.
Tao ZhangCenter for Proteomics and Metabolomics, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.ORCID 0000-0003-0427-9953
Manfred WuhrerCenter for Proteomics and Metabolomics, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.ORCID 0000-0002-0814-4995
Christian StraussDepartment of Neurosurgery, University Hospital Halle, 06120 Halle (Saale), Germany.
Rüdiger HorstkorteMedical Faculty, Institute for Physiological Chemistry, Martin-Luther-University Halle-Wittenberg, 06114 Halle (Saale), Germany.
Maximilian ScheerMedical Faculty, Institute for Physiological Chemistry, Martin-Luther-University Halle-Wittenberg, 06114 Halle (Saale), Germany.ORCID 0000-0003-3149-0797
Martin Luther University Halle-Wittenberg · DELeiden University Medical Center · NLUniversity Hospital in Halle · DE

Funding

Deutsche Forschungsgemeinschaft ProMoAge RTG 2155Wilhelm Roux-program FKZ 31/21
6 · The paper itself

Abstract

Meningiomas are the most common non-malignant intracranial tumors and prefer, like most tumors, anaerobic glycolysis for energy production (Warburg effect). This anaerobic glycolysis leads to an increased synthesis of the metabolite methylglyoxal (MGO) or glyoxal (GO), which is known to react with amino groups of proteins. This reaction is called glycation, thereby building advanced glycation end products (AGEs). In this study, we investigated the influence of glycation on sialylation in two meningioma cell lines, representing the WHO grade I (BEN-MEN-1) and the WHO grade III (IOMM-Lee). In the benign meningioma cell line, glycation led to differences in expression of sialyltransferases (

Indexed as

Cell Line, TumorGene Expression Regulation, EnzymologicGene Expression Regulation, NeoplasticGlycosylationG(M3) GangliosideHumansMeningiomaN-Acetylneuraminic AcidPyruvaldehydeRNA, MessengerSialyltransferasesG(M3) GangliosideN-Acetylneuraminic AcidPyruvaldehydeRNA, MessengerSialyltransferasesintracranial tumormethylglyoxalMGOposttranslational modificationsialylationtumorigenesis

Identifiers

PMID34943806
PMCPMC8699175
OpenAlexW3217236865

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.