Evidence map›Paper›PMID 34943801›Full record

ArticleCells2021

NFAT5/TonEBP Limits Pulmonary Vascular Resistance in the Hypoxic Lung by Controlling Mitochondrial Reactive Oxygen Species Generation in Arterial Smooth Muscle Cells.

Hebatullah Laban, Sophia Siegmund, Maren Zappe, Felix A Trogisch, Jörg Heineke, Carolina De La Torre, Beate Fisslthaler, Caroline Arnold, Jonathan Lauryn, Michael Büttner and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 7 institutions in 2 countries.

Hebatullah LabanInstitute of Physiology and Pathophysiology, Department of Cardiovascular Physiology, Heidelberg University, 69120 Heidelberg, Germany.ORCID 0000-0002-8323-0770
Sophia SiegmundInstitute of Physiology and Pathophysiology, Department of Cardiovascular Physiology, Heidelberg University, 69120 Heidelberg, Germany.
Maren ZappeInstitute of Physiology and Pathophysiology, Department of Cardiovascular Physiology, Heidelberg University, 69120 Heidelberg, Germany.
Felix A TrogischDepartment of Cardiovascular Physiology, Mannheim Medical Faculty, Heidelberg University, 69120 Heidelberg, Germany.ORCID 0000-0002-3513-4362
Jörg HeinekeDepartment of Cardiovascular Physiology, Mannheim Medical Faculty, Heidelberg University, 69120 Heidelberg, Germany.
Carolina De La TorreNGS Core Facility, Medical Faculty Mannheim, Heidelberg University, 69120 Heidelberg, Germany.
Beate FisslthalerInstitute for Vascular Signalling, Goethe University, Frankfurt am Main, 60323 Frankfurt, Germany.
Caroline ArnoldInstitute of Physiology and Pathophysiology, Department of Cardiovascular Physiology, Heidelberg University, 69120 Heidelberg, Germany.
Jonathan LaurynInstitute of Physiology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, 10099 Berlin, Germany.ORCID 0000-0002-8668-8074
Michael BüttnerMetabolomics Core Technology Platform, Centre for Organismal Studies, Heidelberg University, 69120 Heidelberg, Germany.
Carolin MoglerInstitute of Pathology, School of Medicine, Technical University Munich, 80333 Munich, Germany.ORCID 0000-0003-3400-7254
Katsuhiro KatoDepartment of Tissue Morphogenesis, Faculty of Medicine, Max Planck Institute for Molecular Biomedicine, University of Münster, 48149 Münster, Germany.
Ralf H AdamsDepartment of Tissue Morphogenesis, Faculty of Medicine, Max Planck Institute for Molecular Biomedicine, University of Münster, 48149 Münster, Germany.
Hanna KukThe Ottawa Department of Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON K1N 6N5, Canada.
Andreas FischerEuropean Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, 69120 Heidelberg, Germany.ORCID 0000-0002-4889-0909
Markus HeckerInstitute of Physiology and Pathophysiology, Department of Cardiovascular Physiology, Heidelberg University, 69120 Heidelberg, Germany.
Wolfgang M KueblerInstitute of Physiology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, 10099 Berlin, Germany.ORCID 0000-0003-4100-2961
Thomas KorffInstitute of Physiology and Pathophysiology, Department of Cardiovascular Physiology, Heidelberg University, 69120 Heidelberg, Germany.ORCID 0000-0003-2280-3237
Heidelberg University · DEHumboldt-Universität zu Berlin · DEUniversity of Münster · DEGerman Cancer Research Center · DEGoethe University Frankfurt · DETechnical University of Munich · DEUniversity of Ottawa · CA

Funding

Deutsche Forschungsgemeinschaft 394046768-SFB 1366-A1, A6, B5, C4, Z2
6 · The paper itself

Abstract

Chronic hypoxia increases the resistance of pulmonary arteries by stimulating their contraction and augmenting their coverage by smooth muscle cells (SMCs). While these responses require adjustment of the vascular SMC transcriptome, regulatory elements are not well defined in this context. Here, we explored the functional role of the transcription factor nuclear factor of activated T-cells 5 (NFAT5/TonEBP) in the hypoxic lung. Regulatory functions of NFAT5 were investigated in cultured artery SMCs and lungs from control (

Indexed as

Vascular ResistanceAnimalsBlood PressureElectrocardiographyGene Expression RegulationHeart VentriclesHypoxiaLungMetabolomeMiceMitochondriaMyocytes, Smooth MuscleOxidative PhosphorylationOxygen ConsumptionProtein TransportPulmonary ArteryNfat5 protein, mouseReactive Oxygen SpeciesTranscription Factorsmitochondrial ROSNFAT5pulmonary arterysmooth muscle cellstranscriptome

Identifiers

PMID34943801
PMCPMC8699676
OpenAlexW3216646309

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.