Evidence map›Paper›PMID 34943798›Full record

ArticleCells2021

Neuronal Menin Overexpression Rescues Learning and Memory Phenotype in CA1-Specific α7 nAChRs KD Mice.

Shadab Batool, Basma Akhter, Jawwad Zaidi, Frank Visser, Gavin Petrie, Matthew Hill, Naweed I Syed

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Clinically Defined Mutations inCancer research communications · 2023
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Shadab BatoolHotchkiss Brain Institute, University of Calgary, Calgary, AB T2N 4N1, Canada.
Basma AkhterHotchkiss Brain Institute, University of Calgary, Calgary, AB T2N 4N1, Canada.
Jawwad ZaidiCumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.
Frank VisserHotchkiss Brain Institute, University of Calgary, Calgary, AB T2N 4N1, Canada.
Gavin PetrieHotchkiss Brain Institute, University of Calgary, Calgary, AB T2N 4N1, Canada.
Matthew HillHotchkiss Brain Institute, University of Calgary, Calgary, AB T2N 4N1, Canada.
Naweed I SyedDepartment of Cell Biology and Anatomy, University of Calgary, Calgary, AB T2N 4N1, Canada.
University of Calgary · CA

Funding

CIHR 10015088
6 · The paper itself

Abstract

The perturbation of nicotinic cholinergic receptors is thought to underlie many neurodegenerative and neuropsychiatric disorders, such as Alzheimer's and schizophrenia. We previously identified that the tumor suppressor gene,

Indexed as

Memoryalpha7 Nicotinic Acetylcholine ReceptorAnimalsBungarotoxinsCA1 Region, HippocampalDisks Large Homolog 4 ProteinFemaleGene Expression RegulationMiceMice, Inbred C57BLMice, KnockoutNeurogenesisNeuronsOrgan SpecificityPhenotypeProto-Oncogene Proteinsalpha7 Nicotinic Acetylcholine ReceptorBungarotoxinsDisks Large Homolog 4 ProteinDlg4 protein, mouseMen1 protein, mouseProto-Oncogene ProteinsSynaptotagmin ISyt1 protein, mousebrain connectivityextracellular activitylearning and memorymeninnicotinic cholinergic receptorssynaptogenesis

Identifiers

PMID34943798
PMCPMC8699470
OpenAlexW3216836112

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.