Evidence map›Paper›PMID 34943793›Full record

ArticleCells2021

T Cell Interactions in Mycobacterial Granulomas: Non-Specific T Cells Regulate Mycobacteria-Specific T Cells in Granulomatous Lesions.

Dominic O Co, Laura H Hogan, Jozsef Karman, Melinda Herbath, Zsuzsanna Fabry, Matyas Sandor

Open access · goldAbstract read
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Dominic O CoDepartment of Pediatrics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA.ORCID 0000-0001-7760-2411
Laura H HoganThe Institute for Clinical and Translational Research, University of Wisconsin-Madison, Madison, WI 53705, USA.
Jozsef KarmanCambridge Research Center, Abbvie, Inc., Cambridge, MA 02139, USA.
Melinda HerbathDepartment of Pathology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA.ORCID 0000-0002-8403-582X
Zsuzsanna FabryDepartment of Pathology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA.ORCID 0000-0003-4555-9732
Matyas SandorDepartment of Pathology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA.
University of Wisconsin–Madison · USAbbVie (United States) · US

Funding

Secondary infections during mycobacterial diseaseR21AI054893 · NIAID · UNIVERSITY OF WISCONSIN MADISON · PI SANDOR, MATYAS · 2003 to 2004
$432k
NIH HHS R01 AI48087NIH HHS R01 AI/HL46430NIH HHS R21 AI054893
6 · The paper itself

Abstract

Infections with pathogenic mycobacteria are controlled by the formation of a unique structure known as a granuloma. The granuloma represents a host-pathogen interface where bacteria are killed and confined by the host response, but also where bacteria persist. Previous work has demonstrated that the T cell repertoire is heterogenous even at the single granuloma level. However, further work using pigeon cytochrome C (PCC) epitope-tagged BCG (PCC-BCG) and PCC-specific 5CC7 RAG

Indexed as

Cell CommunicationAnimalsAntigens, BacterialConalbuminCytochromes cCytokinesGranulomaImmunizationLymphocyte ActivationMacrophage ActivationMice, TransgenicModels, BiologicalMycobacteriumMycobacterium bovisSpleenT-LymphocytesAntigens, BacterialConalbuminCytochromes cCytokinesgranulomamycobacteriumT cell

Identifiers

PMID34943793
PMCPMC8699651
OpenAlexW3215370312

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.