Evidence map›Paper›PMID 34943784›Full record

ArticleCells2021

Engineered Pullulan-Collagen-Gold Nano Composite Improves Mesenchymal Stem Cells Neural Differentiation and Inflammatory Regulation.

Meng-Yin Yang, Bai-Shuan Liu, Hsiu-Yuan Huang, Yi-Chin Yang, Kai-Bo Chang, Pei-Yeh Kuo, You-Hao Deng, Cheng-Ming Tang, Hsien-Hsu Hsieh, Huey-Shan Hung

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Meng-Yin YangDepartment of Neurosurgery, Neurological Institute, Taichung Veterans General Hospital, Taichung 407204, Taiwan.
Bai-Shuan LiuDepartment of Medical Imaging and Radiological Sciences, Central Taiwan University of Science and Technology, Taichung 406053, Taiwan.
Hsiu-Yuan HuangDepartment of Cosmeceutics and Graduate, Institute of Cosmeceutics, China Medical University, Taichung 40402, Taiwan.
Yi-Chin YangDepartment of Neurosurgery, Neurological Institute, Taichung Veterans General Hospital, Taichung 407204, Taiwan.ORCID 0000-0002-9651-3761
Kai-Bo ChangGraduate Institute of Biomedical Science, China Medical University, Taichung 40402, Taiwan.
Pei-Yeh KuoDepartment of Medical Imaging and Radiological Sciences, Central Taiwan University of Science and Technology, Taichung 406053, Taiwan.
You-Hao DengDepartment of Medical Imaging and Radiological Sciences, Central Taiwan University of Science and Technology, Taichung 406053, Taiwan.
Cheng-Ming TangCollege of Oral Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.ORCID 0000-0003-2103-6670
Hsien-Hsu HsiehBlood Bank, Taichung Veterans General Hospital, Taichung 407024, Taiwan.ORCID 0000-0003-4985-7446
Huey-Shan HungGraduate Institute of Biomedical Science, China Medical University, Taichung 40402, Taiwan.ORCID 0000-0003-4161-2428
Central Taiwan University of Science and Technology · TWChina Medical University · TWTaichung Veterans General Hospital · TWChung Shan Medical University · TWNational Chung Hsing University · TW

Funding

Central Taiwan University CTU108-P-104Taichung Veterans General Hospital TCVGH-1104902BTaichung Veterans General Hospital TCVGH-CTUST1107701
6 · The paper itself

Abstract

Tissue repair engineering supported by nanoparticles and stem cells has been demonstrated as being an efficient strategy for promoting the healing potential during the regeneration of damaged tissues. In the current study, we prepared various nanomaterials including pure Pul, pure Col, Pul-Col, Pul-Au, Pul-Col-Au, and Col-Au to investigate their physicochemical properties, biocompatibility, biological functions, differentiation capacities, and anti-inflammatory abilities through in vitro and in vivo assessments. The physicochemical properties were characterized by SEM, DLS assay, contact angle measurements, UV-Vis spectra, FTIR spectra, SERS, and XPS analysis. The biocompatibility results demonstrated Pul-Col-Au enhanced cell viability, promoted anti-oxidative ability for MSCs and HSFs, and inhibited monocyte and platelet activation. Pul-Col-Au also induced the lowest cell apoptosis and facilitated the MMP activities. Moreover, we evaluated the efficacy of Pul-Col-Au in the enhancement of neuronal differentiation capacities for MSCs. Our animal models elucidated better biocompatibility, as well as the promotion of endothelialization after implanting Pul-Col-Au for a period of one month. The above evidence indicates the excellent biocompatibility, enhancement of neuronal differentiation, and anti-inflammatory capacities, suggesting that the combination of pullulan, collagen, and Au nanoparticles can be potential nanocomposites for neuronal repair, as well as skin tissue regeneration in any further clinical treatments.

Indexed as

Tissue EngineeringCell DifferentiationCells, CulturedGlucansGoldHumansMesenchymal Stem CellsMetal NanoparticlesNanocompositesNeural Stem CellsTissue ScaffoldsGlucansGoldpullulananti-inflammationmesenchymal stem cellsneuronal differentiationpullulan–collagen–gold nanoparticlesskin wound healing

Identifiers

PMID34943784
PMCPMC8699622
OpenAlexW3216483706

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.