Evidence map›Paper›PMID 34943778›Full record

ArticleCells2021

Nuclear Genome-Encoded Long Noncoding RNAs and Mitochondrial Damage in Diabetic Retinopathy.

Ghulam Mohammad, Renu A Kowluru

Open access · goldAbstract read
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
  2. Long Noncoding RNAs as Blood-Based Biomarkers of Diabetic Retinopathy.Translational vision science & technology · 2026
    Article
  3. Mitochondrial Fragmentation and Long Noncoding RNAInternational journal of molecular sciences · 2025
    Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Diabetic Neuropathy of the Retina and Inflammation: Perspectives.International journal of molecular sciences · 2023
    Review
  14. Article
  15. Review
  16. Article
  17. DNA Damage and Repair in Eye Diseases.International journal of molecular sciences · 2023
    Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Ghulam MohammadDepartment of Ophthalmology, Visual & Anatomical Sciences, Wayne State University, Detroit, MI 48201, USA.ORCID 0000-0002-6418-4772
Renu A KowluruKresge Eye Institute, 4717 St. Antoine, Detroit, MI 48201, USA.ORCID 0000-0002-3309-4942
Kresge Eye Institute · USWayne State University · US

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
Role of Ras in Retinal Cell Death in DiabetesR01EY014370 · NEI · WAYNE STATE UNIVERSITY · PI KOWLURU, RENU A. · 2004 to 2023
$4.8M
Glycemic Control and Progression of Diabetic RetinopathyR01EY017313 · NEI · WAYNE STATE UNIVERSITY · PI KOWLURU, RENU A. · 2007 to 2022
$4.2M
NADPH Oxidase, Mitochondrial Dysfunction and Diabetic RetinopathyR01EY022230 · NEI · WAYNE STATE UNIVERSITY · PI KOWLURU, ANJANEYULU, KOWLURU, RENU A. · 2012 to 2022
$3.4M
NEI NIH HHS R01 EY014370NEI NIH HHS R01 EY017313NEI NIH HHS R01 EY022230NIDDK NIH HHS P30 DK020572
6 · The paper itself

Abstract

Retinal mitochondria are damaged in diabetes-accelerating apoptosis of capillary cells, and ultimately, leading to degenerative capillaries. Diabetes also upregulates many long noncoding RNAs (LncRNAs), including Lnc

Indexed as

AnimalsApoptosisCell NucleusDiabetic RetinopathyDNA DamageDNA, MitochondrialEndothelial CellsGene Expression RegulationGenomeGlucoseHumansIn Situ Hybridization, FluorescenceMembrane Potential, MitochondrialMitochondriaRetinaRNA, Long NoncodingDNA, MitochondrialGlucoseMALAT1 long non-coding RNA, humanNEAT1 long non-coding RNA, humanRNA, Long Noncodingdiabetic retinopathylong noncoding RNAmitochondria

Identifiers

PMID34943778
PMCPMC8699566
OpenAlexW3214750500

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.