Evidence map›Paper›PMID 34943767›Full record

ArticleAntibiotics (Basel, Switzerland)2021

Factors Associated with Inadequate Intravenous Colistin Dosages: Post Hoc Analysis of a Multicenter, Cross-Sectional Study.

Daniele Roberto Giacobbe, Michele Mirabella, Matteo Rinaldi, Angela Raffaella Losito, Francesca Raffaelli, Filippo Del Puente, Carolina Saffioti, Malgorzata Mikulska, Maddalena Giannella, Pierluigi Viale and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 66% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 1 country.

Daniele Roberto GiacobbeDepartment of Health Sciences (DISSAL), University of Genoa, 16132 Genoa, Italy.ORCID 0000-0003-2385-1759
Michele MirabellaClinica Malattie Infettive, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.
Matteo RinaldiOperative Unit of Infectious Diseases, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.
Angela Raffaella LositoDipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Roma, Italy.
Francesca RaffaelliDipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Roma, Italy.
Filippo Del PuenteDepartment of Health Sciences (DISSAL), University of Genoa, 16132 Genoa, Italy.
Carolina SaffiotiInfectious Diseases Unit, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.ORCID 0000-0001-5336-0235
Malgorzata MikulskaDepartment of Health Sciences (DISSAL), University of Genoa, 16132 Genoa, Italy.ORCID 0000-0002-5535-4602
Maddalena GiannellaOperative Unit of Infectious Diseases, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.
Pierluigi VialeOperative Unit of Infectious Diseases, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.
Mario TumbarelloDepartment of Medical Biotechnologies, University of Siena, 53100 Siena, Italy.
Matteo BassettiDepartment of Health Sciences (DISSAL), University of Genoa, 16132 Genoa, Italy.
On Behalf Of Sita Giovani Young Investigators Group Of The Società Italiana Terapia Antinfettiva And The Coli-Cross Study Group
Ospedale Policlinico San Martino · ITAzienda USL di Bologna · ITAgostino Gemelli University Polyclinic · ITEnte Ospedaliero Ospedali Galliera · ITIstituto Giannina Gaslini · ITUniversity of Siena · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colistin is a last-resort agent for the treatment of infections due to Gram-negative bacteria with difficult-to-treat resistance. The primary objective of this post hoc analysis of a cross-sectional study conducted in 22 Italian hospitals was to assess factors associated with inadequate intravenous colistin dosage. Overall, 187 patients receiving intravenous colistin were included in the analyses. Inadequate colistin dosages were administered in 27% of cases (50/187). In multivariable analysis, AKI (dummy variable with KDIGO stage 0 as a reference, odds ratio (OR) 3.98 with 95% confidence interval (CI) 1.48-10.74 for stage 1, OR 4.44 with 95% CI 1.17-16.93 for stage 2, OR 9.41 with 95% CI 1.59-55.70 for stage 3; overall

Indexed as

acute kidney injuryantimicrobial stewardshipcolistindosagepolymyxin

Identifiers

PMID34943767
PMCPMC8698974
OpenAlexW4200615939

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.