Evidence map›Paper›PMID 34943668›Full record

ReviewAntibiotics (Basel, Switzerland)2021

Mutational Diversity in the Quinolone Resistance-Determining Regions of Type-II Topoisomerases of

Aqsa Shaheen, Anam Tariq, Mazhar Iqbal, Osman Mirza, Abdul Haque, Thomas Walz, Moazur Rahman

Open access · goldAbstract readReview
In one paragraph

Review in Antibiotics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 49 citations in OpenAlex.

  1. Microbiology spectrum · 2026
    Article
  2. Article
  3. Genomic epidemiology ofOne health (Amsterdam, Netherlands) · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Behavior ofInternational journal of food science · 2026
    Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Quinolone resistance inVeterinary world · 2025
    Article
  16. Article
  17. Article
  18. Article
  19. Antimicrobial resistance inScience in One Health · 2025
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 3 countries.

Aqsa ShaheenDepartment of Biochemistry and Biotechnology, Hafiz Hayat Campus, University of Gujrat, Gujrat 50700, Pakistan.
Anam TariqDrug Discovery and Structural Biology Group, Health Biotechnology Division, National Institute for Biotechnology and Genetic Engineering (NIBGE), Faisalabad 38000, Pakistan.
Mazhar IqbalDrug Discovery and Structural Biology Group, Health Biotechnology Division, National Institute for Biotechnology and Genetic Engineering (NIBGE), Faisalabad 38000, Pakistan.
Osman MirzaDepartment of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Abdul HaqueHuman Infectious Diseases Group, Akhuwat First University, Faisalabad 38000, Pakistan.
Thomas WalzLaboratory of Molecular Electron Microscopy, Rockefeller University, New York, NY 10065, USA.ORCID 0000-0003-2606-2835
Moazur RahmanSchool of Biological Sciences, Quaid-I-Azam Campus, University of the Punjab, Lahore 54590, Pakistan.ORCID 0000-0003-2892-1250
National Institute for Biotechnology and Genetic Engineering · PKRockefeller University · USUniversity of Copenhagen · DKUniversity of Gujrat · PKUniversity of the Punjab · PK

Funding

Higher Education Commission 20-1504 and SRGP 1197
6 · The paper itself

Abstract

Quinolone resistance in bacterial pathogens has primarily been associated with mutations in the quinolone resistance-determining regions (QRDRs) of bacterial type-II topoisomerases, which are DNA gyrase and topoisomerase IV. Depending on the position and type of the mutation (s) in the QRDRs, bacteria either become partially or completely resistant to quinolone. QRDR mutations have been identified and characterized in

Indexed as

DNA gyrasefluoroquinolonesfood-borne pathogensnon-typhoidal Salmonella (NTS)plasmid-mediated quinolone resistance (PMQR)quinolone resistance-determining regions (QRDRs)Salmonellatopoisomerase IVtyphoidal Salmonella

Identifiers

PMID34943668
PMCPMC8698434
OpenAlexW3217152336

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.