ReviewDiagnostics (Basel, Switzerland)2021
State-of-Art in the Age Determination of Venous Thromboembolism: A Systematic Review.
Review in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cadaver clots: a systematic review of the literature.Forensic science, medicine, and pathology · 2025Pooled it
- Violent death and Post-traumatic pulmonary embolism during hospital admission.Forensic science, medicine, and pathology · 2026Article
- Forensic Dating of Venous Thromboembolism: Advances in Histological, Immunohistochemical and Molecular Markers.Diagnostics (Basel, Switzerland) · 2025Review
- Recent Pathophysiological Insights Are Advancing the Treatment of Venous Thromboembolism.JACC. Basic to translational science · 2025Review
- Article
- Forensic approach in cases of anabolic-androgenic steroid abuse and cardiovascular mortality: insights from autopsy, histopathology, immunohistochemistry and toxicology.Frontiers in cardiovascular medicine · 2025Review
- e-Thrombosis: occupation-specific hazard in electronic information and technology professionals.Forensic science, medicine, and pathology · 2024Article
- Trends in mortality related to venous thromboembolism in the European Union, 2012-2020.Internal and emergency medicine · 2024Article
- Fourteen Deaths from Suspected Heparin Overdose in an Italian Primary-Level Hospital.Diagnostics (Basel, Switzerland) · 2023Article
- Agonal Thrombus at Necropsy-A Third Category of Blood Coagulation in Domestic Carnivores.Life (Basel, Switzerland) · 2023Article
- Iatrogenic thrombosis of the deep inferior epigastric artery during diagnostic angiography-a rare complicating factor during rectus free flap harvest.Journal of vascular surgery cases and innovative techniques · 2022Article
- What about cerebral venous sinus thrombosis? A series of three autopsy cases.Legal medicine (Tokyo, Japan) · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Venous thromboembolism (VTE), consisting of deep vein thrombosis (DVT) and pulmonary embolism (PE), requires a forensic age determination to ascertain their causal relationship with recent events, such as trauma or medical treatment. The main objective of this systematic review is to identify the current state-of-the-art immunohistochemical methods for age determination of fatal VTE. A literature search was performed through different databases, according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Within the study, we have selected only cases represented by deceased patients for DVT and/or PTE in which thromboembolic material was collected during an autoptic examination and then subjected to a histological and an immunohistochemical investigation. Studies based on animal models were not included. We assessed bias risk. A database-based search produced a total of 19 articles. After excluding duplicate items from the selection, 14 articles were reviewed. Ten articles were excluded because they did not meet the inclusion criteria. The results have pointed out 4 studies that were included in the present analysis for a total of 157 samples of DVT and 171 PTE samples. These were analyzed using traditional histological and immunohistochemical techniques. The results must be interpreted with a critical eye because of their heterogeneity in terms of time, geography, and study design. The present review highlights the importance of associating specific immunohistochemical markers with a histological analysis for the timing of DVT/PTE fatal events. Further future experiences will hopefully endorse actual knowledge on the subject to increase the accuracy in the assessment of thrombus-embolus age.
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