Evidence map›Paper›PMID 34943621›Full record

ArticleDiagnostics (Basel, Switzerland)2021

Effects of Multi-Shell Free Water Correction on Glioma Characterization.

Lea Starck, Fulvio Zaccagna, Ofer Pasternak, Ferdia A Gallagher, Renate Grüner, Frank Riemer

Abstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Impact of Free Water Correction on the Mean Diffusivity of Glioblastoma is Regional and b-value Dependent: A Retrospective Study on Open-source Datasets.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2026
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  5. Diffusivity-limited q-space trajectory imaging.Magnetic resonance letters · 2023
    Article
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  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lea StarckDepartment of Physics and Technology, University of Bergen, N-5007 Bergen, Norway.ORCID 0000-0003-4996-3038
Fulvio ZaccagnaDepartment of Biomedical and Neuromotor Sciences, University of Bologna, 40125 Bologna, Italy.ORCID 0000-0001-6838-9532
Ofer PasternakDepartment of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA.
Ferdia A GallagherDepartment of Radiology, University of Cambridge, Cambridge CB2 0QQ, UK.ORCID 0000-0003-4784-5230
Renate GrünerDepartment of Physics and Technology, University of Bergen, N-5007 Bergen, Norway.
Frank RiemerMohn Medical Imaging and Visualization Centre (MMIV), Department of Radiology, Haukeland University Hospital, University of Bergen, N-5021 Bergen, Norway.ORCID 0000-0002-3805-5221

Funding

Cancer Research UK 16628Cancer Research UK 27150Cancer Research UK C19212/A16628
6 · The paper itself

Abstract

Diffusion MRI is a useful tool to investigate the microstructure of brain tumors. However, the presence of fast diffusing isotropic signals originating from non-restricted edematous fluids, within and surrounding tumors, may obscure estimation of the underlying tissue characteristics, complicating the radiological interpretation and quantitative evaluation of diffusion MRI. A multi-shell regularized free water (FW) elimination model was therefore applied to separate free water from tissue-related diffusion components from the diffusion MRI of 26 treatment-naïve glioma patients. We then investigated the diagnostic value of the derived measures of FW maps as well as FW-corrected tensor-derived maps of fractional anisotropy (

Indexed as

free watergliomatumor characterization

Identifiers

PMID34943621
PMCPMC8700586

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.