Evidence map›Paper›PMID 34943607›Full record

ArticleDiagnostics (Basel, Switzerland)2021

Increased SERPINA3 Level Is Associated with Ulcerative Colitis.

Jingwei Zhang, Wei Wang, Shenglong Zhu, Yongquan Chen

Open access · goldAbstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Proteases in intestinal health and disease.Nature reviews. Gastroenterology & hepatology · 2026
    Review
  3. Article
  4. Effect of knocking out mouseAmerican journal of physiology. Gastrointestinal and liver physiology · 2024
    Article
  5. Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jingwei ZhangWuxi School of Medicine, Jiangnan University, Wuxi 214122, China.
Wei WangWuxi School of Medicine, Jiangnan University, Wuxi 214122, China.
Shenglong ZhuWuxi School of Medicine, Jiangnan University, Wuxi 214122, China.
Yongquan ChenWuxi School of Medicine, Jiangnan University, Wuxi 214122, China.
Jiangnan University · CN

Funding

Fundamental Research Funds for the Central Universities JUSRP12048Fund of Wuxi Healthcare Commission M202004Innovation and Application Project of Medical and Public Health Technology of Wuxi Science and Technology N20202005Key Research and Development Program of Jiangsu Province BE2018624Major Special Fund for Translational Medicine 2020ZHZD03National Natural Science Foundation of China 31771539National Natural Science Foundation of China 82000808
6 · The paper itself

Abstract

Ulcerative colitis (UC) is a recurrent, chronic intestinal disease that is currently incurable. Its pathogenesis remains to be further understood. Therefore, seeking new biomarkers and potential drug targets is urgent for the effective treatment of UC. In this study, the gene expression profile GSE38713 was obtained from the GEO (Gene Expression Omnibus) database. Data normalisation and screening of the differentially expressed genes (DEGs) were conducted using R software, and gene ontology (GO) enrichment was performed using Metascape online tools. The PubMed database was used to screen new genes that have not been reported, and

Indexed as

biomarkerSERPINA3ulcerative colitis

Identifiers

PMID34943607
PMCPMC8700084
OpenAlexW4200017855

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.