Evidence map›Paper›PMID 34943570›Full record

ReviewDiagnostics (Basel, Switzerland)2021

Absolute Quantification in Diagnostic SPECT/CT: The Phantom Premise.

Stijn De Schepper, Gopinath Gnanasegaran, John C Dickson, Tim Van den Wyngaert

Abstract readReview
In one paragraph

Review in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Quantitative SPECT/CT: Technique and Clinical Applications.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026
    Review
  3. Article
  4. Article
  5. Brachytherapy and 3D printing for skin cancer: A review paper.Journal of contemporary brachytherapy · 2024
    Review
  6. Article
  7. Association between body mass index (BMI) and [European journal of hybrid imaging · 2023
    Article
  8. Article
  9. Article
  10. Editorial on Special Issue "Quantitative PET and SPECT".Diagnostics (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Stijn De SchepperDepartment of Nuclear Medicine, Antwerp University Hospital, 2650 Edegem, Belgium.ORCID 0000-0003-4194-0974
Gopinath GnanasegaranDepartment of Nuclear Medicine, Royal Free London NHS, London NW3 2QG, UK.
John C DicksonInstitute of Nuclear Medicine, University College of London Hospitals NHS, London NW1 2BU, UK.ORCID 0000-0002-1793-3822
Tim Van den WyngaertDepartment of Nuclear Medicine, Antwerp University Hospital, 2650 Edegem, Belgium.ORCID 0000-0002-0320-9075

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The application of absolute quantification in SPECT/CT has seen increased interest in the context of radionuclide therapies where patient-specific dosimetry is a requirement within the European Union (EU) legislation. However, the translation of this technique to diagnostic nuclear medicine outside this setting is rather slow. Clinical research has, in some examples, already shown an association between imaging metrics and clinical diagnosis, but the applications, in general, lack proper validation because of the absence of a ground truth measurement. Meanwhile, additive manufacturing or 3D printing has seen rapid improvements, increasing its uptake in medical imaging. Three-dimensional printed phantoms have already made a significant impact on quantitative imaging, a trend that is likely to increase in the future. In this review, we summarize the data of recent literature to underpin our premise that the validation of diagnostic applications in nuclear medicine using application-specific phantoms is within reach given the current state-of-the-art in additive manufacturing or 3D printing.

Indexed as

3D printingabsolute quantificationdiagnosticsphantomsSPECT/CT

Identifiers

PMID34943570
PMCPMC8700635

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.