ArticleDiagnostics (Basel, Switzerland)2021
Quantification of Sodium Relaxation Times and Concentrations as Surrogates of Proteoglycan Content of Patellar CARTILAGE at 3T MRI.
Article in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 14 citations in OpenAlex.
- Repeatability of SimultaneousNMR in biomedicine · 2026Article
- Evaluation of Partial Volume Correction Techniques for Sodium MRI of the Achilles Tendon.Magnetic resonance in medicine · 2026Article
- Polyacrylamide Gel Calibration Phantoms for Quantification in Sodium MRI.NMR in biomedicine · 2025Article
- Sodium MRI of the Lumbar Intervertebral Discs of the Human Spine: An Ex Vivo Study.Journal of magnetic resonance imaging : JMRI · 2025Article
- Beyond the Surface: Nutritional Interventions Integrated with Diagnostic Imaging Tools to Target and Preserve Cartilage Integrity: A Narrative Review.Biomedicines · 2025Review
- Quantitative and Compositional MRI of the Articular Cartilage: A Narrative Review.Tomography (Ann Arbor, Mich.) · 2024Review
- A systematic review demonstrating correlation of MRI compositional parameters with clinical outcomes following articular cartilage repair interventions in the knee.Osteoarthritis and cartilage open · 2023Review
- MR-Imaging in Osteoarthritis: Current Standard of Practice and Future Outlook.Diagnostics (Basel, Switzerland) · 2023Review
- Insights into the Age Dependency of Compositional MR Biomarkers Quantifying the Health Status of Cartilage in Metacarpophalangeal Joints.Diagnostics (Basel, Switzerland) · 2023Article
- Review
- Evaluation of Sodium Relaxation Times and Concentrations in the Achilles Tendon Using MRI.International journal of molecular sciences · 2022Article
- Lorentzian-Corrected Apparent Exchange-Dependent Relaxation (LAREX) Ω-Plot Analysis-An Adaptation for qCEST in a Multi-Pool System: Comprehensive In Silico, In Situ, and In Vivo Studies.International journal of molecular sciences · 2022Article
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
Sodium MRI has the potential to depict cartilage health accurately, but synovial fluid can influence the estimation of sodium parameters of cartilage. Therefore, this study aimed to reduce the impact of synovial fluid to render the quantitative compositional analyses of cartilage tissue technically more robust. Two dedicated protocols were applied for determining sodium T1 and T2* relaxation times. For each protocol, data were acquired from 10 healthy volunteers and one patient with patellar cartilage damage. Data recorded with multiple repetition times for T1 measurement and multi-echo data acquired with an additional inversion recovery pulse for T2* measurement were analysed using biexponential models to differentiate longitudinal relaxation components of cartilage (T1,car) and synovial fluid (T1,syn), and short (T2s*) from long (T2l*) transversal relaxation components. Sodium relaxation times and concentration estimates in patellar cartilage were successfully determined: T1,car = 14.5 ± 0.7 ms; T1,syn = 37.9 ± 2.9 ms; c(T1-protocol) = 200 ± 48 mmol/L; T2s* = 0.4 ± 0.1 ms; T2l* = 12.6 ± 0.7 ms; c(T2*-protocol) = 215 ± 44 mmol/L for healthy volunteers. In conclusion, a robust determination of sodium relaxation times is possible at a clinical field strength of 3T to quantify sodium concentrations, which might be a valuable tool to determine cartilage health.
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