Evaluation of Cumulative Effect of Standard Triple Immunosuppression on Prevention of De Novo Donor Specific Antibodies (dnDSA) Production in Children after Kidney Transplantation-A Retrospective and Prospective Study.

Agnieszka Urzykowska, Barbara Piątosa, Urszula Grycuk, Grzegorz Kowalewski, Zbigniew Kułaga, Ryszard Grenda

Open access · goldAbstract read

In one paragraph

Article in Children (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.2field-weighted citation impact, top 48% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Agnieszka UrzykowskaDepartment of Nephrology, Kidney Transplantation & Hypertension, Children's Memorial Health Institute, 04-730 Warsaw, Poland.

Barbara PiątosaHistocompatibility Laboratory, Children's Memorial Health Institute, 04-730 Warsaw, Poland.

Urszula GrycukHistocompatibility Laboratory, Children's Memorial Health Institute, 04-730 Warsaw, Poland.

Grzegorz KowalewskiDepartment of Surgery and Organ Transplantation, Children's Memorial Health Institute, 04-730 Warsaw, Poland.ORCID 0000-0001-7183-7711

Zbigniew KułagaDepartment of Public Health, Children's Memorial Health Institute, 04-730 Warsaw, Poland.ORCID 0000-0003-0509-1004

Ryszard GrendaDepartment of Nephrology, Kidney Transplantation & Hypertension, Children's Memorial Health Institute, 04-730 Warsaw, Poland.ORCID 0000-0002-6814-6589

Children's Memorial Health Institute · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

De novo Donor Specific Antibodies (dnDSA) are associated with inferior graft outcomes. Standard immunosuppression is expected to prevent dnDSA production in low-risk patients. We have evaluated a cumulative effect of a triple immunosuppression (CNI/MMF/Pred), as well as TAC concentration and coefficient of variation on the incidence of dnDSA production. Overall, 67 transplanted patients were evaluated in retrospective (dnDSA for-cause;

Indexed as

cumulative strength of immunosuppressiondnDSAkidney transplantationTAC variability and concentrationVasudev score

Identifiers

PMID34943360

DOI10.3390/children8121162

PMCPMC8700537

OpenAlexW4200441137

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.