ArticleChildren (Basel, Switzerland)2021
Validating a Minimally Invasive Tissue Sampling (MITS) Method in Determining Cause of Death in Stillbirths and Neonates.
Article in Children (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Validation of malaria-attributed deaths using verbal autopsy studies: a systematic review.Malaria journal · 2024Pooled it
- Standardization of minimally invasive tissue sampling (MITS) technique for intestinal sampling in neonatal autopsies.Forensic science, medicine, and pathology · 2026Article
- Rationale and Design of the MIA Trial: A Proof-of-Concept Study of Minimally Invasive Autopsy in an Infectious Cause of Death in a Scandinavian ICU Setting.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2026Review
- Exploring minimally invasive tissue sampling as an alternative to conventional autopsy in neonatal deaths.Forensic science, medicine, and pathology · 2026Observational
- Diagnostic accuracy of a simplified minimally invasive tissue sampling protocol for stillbirths in low-resource settings.BMJ global health · 2025Article
- Modeling and Exploring Stillbirth Risks in Northern Pakistan.Healthcare (Basel, Switzerland) · 2025Article
- Fetal Death Due to an Unusual Coexistence of Two Umbilical Cord Anomalies: Analysis in a Forensic Perspective.Diagnostics (Basel, Switzerland) · 2025Article
- Understanding the clinical utility of stillbirth investigations: a scoping review.BMC pregnancy and childbirth · 2025Article
- Acceptability of minimal invasive tissue sampling (MITS) for stillbirths in Eastern Uganda.PloS one · 2025Article
- Infectious Causes of Stillbirths: A Descriptive Etiological Study in Uganda.Open forum infectious diseases · 2024Article
- "Ethiopian journal of health sciences · 2024Article
- The discrepancy of antemortem clinical diagnosis and postmortem autopsy diagnosis of lung pathologies in under-five deaths and the reasons for discrepancies: a case series analysis.BMC pediatrics · 2024Article
- Postmortem minimally invasive tissue sampling in communities: exploring perceptions of families, funeral workers, religious and community leaders and healthcare providers from Pakistan.BMC health services research · 2023Article
- Verbal Autopsy to Assess Postdischarge Mortality in Children With Suspected Sepsis in Uganda.Pediatrics · 2023Article
- Provider adherence to clinical care recommendations for infants and children who died in seven low- and middle-income countries in the Child Health and Mortality Prevention Surveillance (CHAMPS) network.EClinicalMedicine · 2023Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Complete diagnostic autopsy (CDA) remains the gold standard and a valuable technique for determining cause of death. It is a source of health statistics that can be used to measure health care services' quality, unraveling important information on disease processes, particularly in emerging and unknown diseases. It can also be a vital tool for medical education and biomedical research. However, autopsy rates have been declining globally. There is an urgent need to develop and validate alternative methods in different settings to provide reliable information on cause of death. In this study, we aimed to determine cause of death (KazCoDe) in neonates and infants using minimally invasive tissue sampling (MITS), and to compare these results with those of CDA. We conducted MITS and CDA sequentially on 24 deceased children at the Pathological Bureau of the Akimat of the city of Nur-Sultan. Clinical data of the study subjects were extracted from their clinical records. During both procedures, brain, liver and lung tissues were collected for pathological diagnosis. Fifteen (62.5%) and nine (37.5%) were stillbirths and neonates, respectively. Eight (33.3%) were females and 16 (66.7%) were males. MITS diagnosis of cause of death was concordant with CDA diagnosis in 83.3% out of the 24 cases when considering the immediate and underlying causes of death and reviewing all the clinical and laboratory test results as part of the diagnostic evaluation to arrive at a cause of death (ICD-PM). We concluded that MITS is a valuable and reliable method for cause of death diagnosis in stillbirths and neonates, which can contribute vital mortality statistics in children in the absence of CDA.
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