Evidence map›Paper›PMID 34943265›Full record

ReviewBiology2021

Diagnostic and Prognostic Value of miRNAs after Coronary Artery Bypass Grafting: A Review.

Ewelina Błażejowska, Tomasz Urbanowicz, Aleksandra Gąsecka, Anna Olasińska-Wiśniewska, Miłosz J Jaguszewski, Radosław Targoński, Łukasz Szarpak, Krzysztof J Filipiak, Bartłomiej Perek, Marek Jemielity

Open access · goldAbstract readReview
In one paragraph

Review in Biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Ewelina Błażejowska1st Chair and Department of Cardiology, Medical University of Warsaw, 02-091 Warsaw, Poland.ORCID 0000-0001-6924-0051
Tomasz UrbanowiczCardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, 61-701 Poznan, Poland.ORCID 0000-0001-8080-2764
Aleksandra Gąsecka1st Chair and Department of Cardiology, Medical University of Warsaw, 02-091 Warsaw, Poland.ORCID 0000-0001-5083-7587
Anna Olasińska-WiśniewskaCardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, 61-701 Poznan, Poland.ORCID 0000-0002-4213-8708
Miłosz J Jaguszewski1st Department of Cardiology, Medical University of Gdansk, 80-211 Gdansk, Poland.ORCID 0000-0002-2555-593X
Radosław Targoński1st Department of Cardiology, Medical University of Gdansk, 80-211 Gdansk, Poland.ORCID 0000-0001-9296-7283
Łukasz SzarpakDepartment of Clinical Sciences, Maria Sklodowska-Curie Medical Academy, 03-411 Warsaw, Poland.ORCID 0000-0002-0973-5455
Krzysztof J FilipiakDepartment of Clinical Sciences, Maria Sklodowska-Curie Medical Academy, 03-411 Warsaw, Poland.ORCID 0000-0002-6563-0877
Bartłomiej PerekCardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, 61-701 Poznan, Poland.ORCID 0000-0003-2398-9571
Marek JemielityCardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, 61-701 Poznan, Poland.
Poznan University of Medical Sciences · PLGdańsk Medical University · PLMedical University of Warsaw · PL

Funding

National Science Center 2018/31/N/NZ7/02260
6 · The paper itself

Abstract

MiRNAs are noncoding, 21-24 nucleotide-long RNA particles that control over 60% of genes. MiRNAs affect gene expression through binding to the 3'-untranslated region of messenger RNA (mRNA), thus inhibiting mRNA translation or inducing mRNA degradation. MiRNAs have been associated with various cardiovascular diseases, including heart failure, hypertension, left ventricular hypertrophy, or ischemic heart disease. In addition, miRNA expression alters during coronary artery bypass grafting (CABG) surgery, which could be used to predict perioperative outcomes. CABG is an operation in which complex coronary arteries stenosis is treated by bypassing atherosclerotic lesions with venous or arterial grafts. Despite a very low perioperative mortality rate and excellent long-term survival, CABG is associated with postoperative complications, including reperfusion injury, graft failure, atrial fibrillation and perioperative myocardial infarction. So far, no reliable diagnostic and prognostic tools to predict prognosis after CABG have been developed. Changes in the perioperative miRNA expression levels could improve the diagnosis of post-CABG myocardial infarction and atrial fibrillation and could be used to stratify risk after CABG. Herein, we describe the expression changes of different subtypes of miRNAs during CABG and review the diagnostic and prognostic utility of miRNAs in patients undergoing CABG.

Indexed as

biomarkerscoronary artery bypass graftingcoronary artery diseasediagnosismiRNAprognosis

Identifiers

PMID34943265
PMCPMC8698870
OpenAlexW4200100300

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.