ArticleBiology2021
Itch in Adult Population with Type 2 Diabetes Mellitus: Clinical Profile, Pathogenesis and Disease-Related Burden in a Cross-Sectional Study.
Article in Biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- The effect of medication use on chronic pruritus in patients with type 2 diabetes mellitus: a multicenter cross-sectional study.Scientific reports · 2026Article
- Chronic Pruritus in Older Adults: Prevalence, Associations, and Pruritus-specific Quality of Life.Acta dermato-venereologica · 2025Article
- CKD-associated pruritus in haemodialysis: a road map for diagnosis and treatment.Clinical kidney journal · 2025Review
- Molecular and cellular mechanisms of itch sensation and the anti-itch drug targets.Acta pharmacologica Sinica · 2025Review
- Article
- Pruritus prevalence and characteristics in Care and Treatment Facility and Geriatric Outpatient Clinic patients: a cross-sectional study using a standardized pruritus questionnaires.Postepy dermatologii i alergologii · 2024Article
- Chronic Itch Affects Patients' Ability to Experience Pleasure: Anhedonia in Itchy Disorders.Acta dermato-venereologica · 2024Article
- Orexin neurons play contrasting roles in itch and pain neural processing via projecting to the periaqueductal gray.Communications biology · 2024Article
- Cutaneous Manifestations Associated with Diabetes Mellitus-A Retrospective Study.Diseases (Basel, Switzerland) · 2023Article
- Survey of factors related to diabetic foot pruritus in the elderly in Shanghai.International wound journal · 2023Article
- Prevalence, Intensity and Psychosocial Burden of Acne Itch: Two Different Cohorts Study.Journal of clinical medicine · 2023Article
- An Anterior Cingulate Cortex-to-Midbrain Projection Controls Chronic Itch in Mice.Neuroscience bulletin · 2023Article
- Serum Mediators in Patients with Both Type 2 Diabetes Mellitus and Pruritus.Acta dermato-venereologica · 2023Article
- Changes in multimorbidity burden over a 3-5 year period among people with HIV.Frontiers in systems biology · 2023Article
- Impact of Chronic Kidney Disease Severity on the Risk of Prurigo Nodularis: A Population-Based Cohort Study.Acta dermato-venereologica · 2022Article
- Alterations in epidermal function in type 2 diabetes: Implications for the management of this disease.Journal of diabetes · 2022Review
- Small-fibre Neuropathy in Patients with Type 2 Diabetes Mellitus and its Relationship with Diabetic Itch: Preliminary Results.Acta dermato-venereologica · 2022Article
- Article
- Improvement of Quality of Life in Dialysis and Diabetic Patients by Skin Dryness and Pruritus Management with an Ecobiological Dermo-Cosmetic Product.Clinical, cosmetic and investigational dermatology · 2022Article
- Neuroinflammation Involved in Diabetes-Related Pain and Itch.Frontiers in pharmacology · 2022Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundDespite growing interest in itch, data regarding itch in type 2 diabetes mellitus (DM2) are still limited, and mostly based on outdated studies. This study aimed to evaluate the clinical characteristics of itch in the adult population with DM2 and explore potential underlying causes.
methodsThe study group consisted of 109 adult patients with DM2. Standardized questionnaires were completed in order to assess the itch intensity [Numerical Rating Scale (three days, 24hours) (NRS)] and the Four-item Itch Questionnaire (4IIQ) and to assess the psychological impact of itch [ItchyQoL, Six-Item Stigmatization Scale (6-ISS), Hospital Anxiety and Depression Scale (HADS)]. Skin dryness was evaluated clinically and by non-invasive assessment of epidermis moisturizing. Neuropathy was assessed using the clinical Katzenwadel neuropathy scale.
resultsItch occurred in 35.8% of adult patients with DM2, with NRS
conclusionsWe suggest that the primary cause of itch is prolonged poor diabetes control with altered glucose and insulin levels, subsequently causing skin dryness and neuropathy in long-lasting DM2.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.