Evidence map›Paper›PMID 34943065›Full record

ArticleAntioxidants (Basel, Switzerland)2021

Hibiscus Flower and Olive Leaf Extracts Activate Apoptosis in SH-SY5Y Cells.

Elda Chiaino, Matteo Micucci, Roberta Budriesi, Laura Beatrice Mattioli, Carla Marzetti, Maddalena Corsini, Maria Frosini

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. International journal of molecular sciences · 2026
    Article
  3. Protective effects of roselle (Journal of toxicologic pathology · 2025
    Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Nutrients · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Elda ChiainoDipartimento di Scienze della Vita, Università di Siena, Via Aldo Moro 2, 53100 Siena, Italy.
Matteo MicucciDipartimento di Farmacia e Biotecnologie, Alma Mater Studiorum-Università di Bologna, Via Belmeloro, 40126 Bologna, Italy.ORCID 0000-0003-3525-1531
Roberta BudriesiDipartimento di Farmacia e Biotecnologie, Alma Mater Studiorum-Università di Bologna, Via Belmeloro, 40126 Bologna, Italy.ORCID 0000-0002-8454-9740
Laura Beatrice MattioliDipartimento di Farmacia e Biotecnologie, Alma Mater Studiorum-Università di Bologna, Via Belmeloro, 40126 Bologna, Italy.
Carla MarzettiValsambro S.r.l., Via Cairoli 2, 40121 Bologna, Italy.
Maddalena CorsiniDipartimento di Biotecnologie Chimica e Farmacia, Università di Siena, Via Aldo Moro 2, 53100 Siena, Italy.ORCID 0000-0002-5920-5436
Maria FrosiniDipartimento di Scienze della Vita, Università di Siena, Via Aldo Moro 2, 53100 Siena, Italy.ORCID 0000-0002-4452-8128
University of Siena · ITUniversity of Bologna · ITOspedale Valduce · ITSaint Camillus International University of Health and Medical Sciences · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Compounds of natural origin may constitute an interesting tool for the treatment of neuroblastoma, the most prevalent extracranial solid tumor in children. PRES is a commercially available food supplement, composed of a 13:2 (

Indexed as

apoptosiscancercaspaseshibiscus acidHibiscus sabdariffa L.natural compoundsneuroblastomaOlea europea L.oleuropein

Identifiers

PMID34943065
PMCPMC8750347
OpenAlexW4200208219

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.