Evidence map›Paper›PMID 34943016›Full record

ArticleAntioxidants (Basel, Switzerland)2021

Endothelial

Ahmed Elsaie, Renuka T Menon, Amrit K Shrestha, Sharada H Gowda, Nidhy P Varghese, Roberto J Barrios, Cynthia L Blanco, Girija G Konduri, Binoy Shivanna

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. AMPK Activation: Respiratory Panacea?American journal of respiratory cell and molecular biology · 2023
    Article
  9. Molecular mechanisms of cell death in bronchopulmonary dysplasia.Apoptosis : an international journal on programmed cell death · 2023
    Review
  10. Article
  11. The role and mechanism of AMPK in pulmonary hypertension.Therapeutic advances in respiratory disease
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Ahmed ElsaieDepartment of Pediatrics, Neonatology Section, Baylor College of Medicine (BCM), Houston, TX 77030, USA.
Renuka T MenonDepartment of Pediatrics, Neonatology Section, Baylor College of Medicine (BCM), Houston, TX 77030, USA.
Amrit K ShresthaDepartment of Pediatrics, Neonatology Section, Baylor College of Medicine (BCM), Houston, TX 77030, USA.
Sharada H GowdaDepartment of Pediatrics, Neonatology Section, Baylor College of Medicine (BCM), Houston, TX 77030, USA.ORCID 0000-0001-7009-4821
Nidhy P VargheseDepartment of Pediatrics, Pulmonology Section, Baylor College of Medicine (BCM), Houston, TX 77030, USA.
Roberto J BarriosDepartment of Pathology, Houston Methodist Hospital, Houston, TX 77030, USA.
Cynthia L BlancoDepartment of Pediatrics, Division of Neonatology, University of Texas Health Science Center, San Antonio, TX 78229, USA.
Girija G KonduriDepartment of Pediatrics, Division of Neonatology, Children's Research Institute, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Binoy ShivannaDepartment of Pediatrics, Neonatology Section, Baylor College of Medicine (BCM), Houston, TX 77030, USA.ORCID 0000-0001-8119-5783
Baylor College of Medicine · USCairo University · EGChildren's Hospital of Wisconsin · USMethodist Hospital · USThe University of Texas Health Science Center at San Antonio · US

Funding

Mechanistic Roles of Adrenomedullin and its Signaling Receptors in Experimental Bronchopulmonary Dysplasia and Pulmonary HypertensionR01HL139594 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI SHIVANNA, BINOY · 2018 to 2022
$2.0M
NHLBI NIH HHS R01 HL139594NIH HHS HL139594
6 · The paper itself

Abstract

Bronchopulmonary dysplasia and pulmonary hypertension, or BPD-PH, are serious chronic lung disorders of prematurity, without curative therapies. Hyperoxia, a known causative factor of BPD-PH, activates adenosine monophosphate-activated protein kinase (AMPK) α1 in neonatal murine lungs; however, whether this phenomenon potentiates or mitigates lung injury is unclear. Thus, we hypothesized that (1) endothelial

Indexed as

AMPKα1bronchopulmonary dysplasiahyperoxianeonatal HPMECspulmonary hypertension

Identifiers

PMID34943016
PMCPMC8750184
OpenAlexW3214908178

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.