ArticleBrain sciences2021
Cognitive and Neural Mechanisms of Social Communication Dysfunction in Primary Progressive Aphasia.
Article in Brain sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Enigma of autism regression mechanistic pathways, clinical phenotypes, and early intervention implications.World journal of clinical pediatrics · 2026Review
- Safety and Efficacy of Different Therapeutic Interventions for Primary Progressive Aphasia: A Systematic Review.Journal of clinical medicine · 2025Review
- Comprehension of acoustically degraded emotional prosody in Alzheimer's disease and primary progressive aphasia.Scientific reports · 2024Article
- Advancing Neuropsychological Rehabilitation in Primary Progressive Aphasia Based on Principles of Cognitive Neuroscience: A Scoping Review and Systematic Analysis of the Data.Brain sciences · 2024Article
- A novel end-to-end dual-camera system for eye gaze synchrony assessment in face-to-face interaction.Attention, perception & psychophysics · 2024Article
- Social Communication Delay in an Unbiased Sample of Preschoolers With theJournal of speech, language, and hearing research : JSLHR · 2024Article
- Symptom-led staging for semantic and non-fluent/agrammatic variants of primary progressive aphasia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Symptom-led staging for primary progressive aphasia.medRxiv : the preprint server for health sciences · 2023Article
- Understanding the multidimensional cognitive deficits of logopenic variant primary progressive aphasia.Brain : a journal of neurology · 2022Review
- Impairments in knowledge of social norms in presymptomatic, prodromal, and symptomatic frontotemporal dementia.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Mounting evidence suggests that, in parallel with well-defined changes in language, primary progressive aphasia (PPA) syndromes display co-occurring social cognitive impairments. Here, we explored multidimensional profiles of carer-rated social communication using the La Trobe Communication Questionnaire (LCQ) in 11 semantic dementia (SD), 12 logopenic progressive aphasia (LPA) and 9 progressive non-fluent aphasia (PNFA) cases and contrasted their performance with 19 Alzheimer's disease (AD) cases, 26 behavioural variant frontotemporal dementia (bvFTD) cases and 31 healthy older controls. Relative to the controls, the majority of patient groups displayed significant overall social communication difficulties, with common and unique profiles of impairment evident on the LCQ subscales. Correlation analyses revealed a differential impact of social communication disturbances on functional outcomes in patient and carer well-being, most pronounced for SD and bvFTD. Finally, voxel-based morphometry analyses based on a structural brain MRI pointed to the degradation of a distributed brain network in mediating social communication dysfunction in dementia. Our findings suggest that social communication difficulties are an important feature of PPA, with significant implications for patient function and carer well-being. The origins of these changes are likely to be multifactorial, reflecting the breakdown of fronto-thalamic brain circuits specialised in the integration of complex information.
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Registered trials
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