ReviewBrain sciences2021
Neurophysiological Aspects of REM Sleep Behavior Disorder (RBD): A Narrative Review.
Review in Brain sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06140511 (DREAMER - IsolateD REM Sleep Without Atonia as a Risk Factor for REM Sleep Behavior disordER), which is not on this map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
DREAMER - IsolateD REM Sleep Without Atonia as a Risk Factor for REM Sleep Behavior disordER: Constitution of a Cohort for a Long-term Prospective Follow-up Study
Who cites it
34 citing papers in PubMed, 47 citations in OpenAlex.
- MAF-SleepNet: A Multimodal Attention-Enhanced Fusion Network for Automatic Multi-Class Sleep Disorder Classification from Polysomnography.Diagnostics (Basel, Switzerland) · 2026Article
- Exercise Intervention for REM Sleep Behavior Disorder in Parkinson's Disease: Mechanisms and Implications for Neurorehabilitation.CNS neuroscience & therapeutics · 2026Review
- Update on Repetitive Transcranial Magnetic Stimulation in Post-Stroke Cognitive Rehabilitation: A Systematic Review of Randomized Clinical Trials.Life (Basel, Switzerland) · 2026Review
- Dream-enactment behaviors without REM sleep without atonia.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026Article
- Comparison of EMG, Video, and Actigraphy Signals for Detecting Motor Activity in REM Sleep Behavior Disorder.Diagnostics (Basel, Switzerland) · 2026Article
- Speech and Language Changes During Rapid Eye Movement (REM) Sleep with Potential Diagnostic Markers: A Systematic Review.Brain sciences · 2026Review
- Transcranial Magnetic Stimulation in Parkinson's Disease and Parkinsonian Syndromes: A Narrative Expert Review.Life (Basel, Switzerland) · 2026Review
- Article
- Emerging neurotechnological approaches to management of sleep disturbances in Parkinson's disease.Clinical parkinsonism & related disorders · 2026Review
- Observational
- Article
- Improvement in sleep following treatment initiation in newly diagnosed, treatment-naïve patients with Wilson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Protein Expression of TXNIP in the Dopaminergic Neurons of Subjects with Parkinson's Disease: Evidence from a Pilot Study.Life (Basel, Switzerland) · 2025Article
- Neuroprotective effects of rTMS in chronic insomnia: is glymphatic system modulation the key player?Sleep · 2025Article
- Article
- From mechanisms to future therapy: a synopsis of isolated REM sleep behavior disorder as early synuclein-related disease.Molecular neurodegeneration · 2025Review
- Altered effective connectivity in Parkinson's disease patients with rapid eye movement sleep behavior disorder: a resting-state functional magnetic resonance imaging study and support vector machine analysis.Quantitative imaging in medicine and surgery · 2025Article
- Circadian and sleep-wake rhythm alterations in isolated REM sleep behavior disorder: biomarkers of prodromal α-synucleinopathy.Frontiers in neuroscience · 2025Review
- Intersection of Sleep Disorders and Parkinson Disease: Unveiling the Bidirectional Relationship.Movement disorders clinical practice · 2025Review
- Machine Learning Predicts Phenoconversion from Polysomnography in Isolated REM Sleep Behavior Disorder.Brain sciences · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
REM sleep without atonia (RSWA) is the polysomnographic (PSG) hallmark of rapid eye movement (REM) sleep behavior disorder (RBD), a feature essential for the diagnosis of this condition. Several additional neurophysiological aspects of this complex disorder have also recently been investigated in depth, which constitute the focus of this narrative review, together with RSWA. First, we describe the complex neural network underlying REM sleep and its muscle atonia, focusing on the disordered mechanisms leading to RSWA. RSWA is then described in terms of its polysomnographic features, and the methods (visual and automatic) currently available for its scoring and quantification are exposed and discussed. Subsequently, more recent and advanced neurophysiological features of RBD are described, such as electroencephalography during wakefulness and sleep, transcranial magnetic stimulation, and vestibular evoked myogenic potentials. The role of the assessment of neurophysiological features in the study of RBD is then carefully discussed, highlighting their usefulness and sensitivity in detecting neurodegeneration in the early or prodromal stages of RBD, as well as their relationship with other proposed biomarkers for the diagnosis, prognosis, and monitoring of this condition. Finally, a future research agenda is proposed to help clarify the many still unclear aspects of RBD.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.