ArticleBrain sciences2021
The Role of the Human Brain Neuron-Glia-Synapse Composition in Forming Resting-State Functional Connectivity Networks.
Article in Brain sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Nanotechnology in Pediatric Neurology: Applications and Innovations.Pharmaceutics · 2026Review
- Intelligent diagnosis of major depressive disorder with edge convolution and contrastive learning.PloS one · 2026Article
- Explainable 3D CNNs link regional and network level disruption in early Parkinson's MRIs to symptom progression.bioRxiv : the preprint server for biology · 2025Article
- The intrinsic time tracker: temporal context is embedded in entorhinal and hippocampal functional connectivity patterns.Nature communications · 2025Article
- Unraveling the major role of vascular (R2') contributions to R2* signal relaxation at ultra-high-field MRI: A comprehensive analysis with quantitative gradient recalled echo in mouse brain.Magnetic resonance in medicine · 2025Article
- Adolescent substance use trajectories are associated with nucleus accumbens functional connectivity.Journal of psychopharmacology (Oxford, England) · 2025Article
- The interaction between resilience framework and neuron-astrocyte-synapse dynamics in AD.Frontiers in aging neuroscience · 2025Review
- Zika virus encephalitis causes transient reduction of functional cortical connectivity.Neurophotonics · 2025Article
- The efficacy of topological properties of functional brain networks in identifying major depressive disorder.Scientific reports · 2024Article
- Prolonged microgravity induces reversible and persistent changes on human cerebral connectivity.Communications biology · 2023Article
- Intelligent diagnosis of major depression disease based on multi-layer brain network.Frontiers in neuroscience · 2023Article
- Trends in Gliosis in Obesity, and the Role of Antioxidants as a Therapeutic Alternative.Antioxidants (Basel, Switzerland) · 2022Review
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Authors and funding
3 authors.
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Abstract
While significant progress has been achieved in studying resting-state functional networks in a healthy human brain and in a wide range of clinical conditions, many questions related to their relationship to the brain's cellular constituents remain. Here, we use quantitative Gradient-Recalled Echo (qGRE) MRI for mapping the human brain cellular composition and BOLD (blood-oxygen level-dependent) MRI to explore how the brain cellular constituents relate to resting-state functional networks. Results show that the BOLD signal-defined synchrony of connections between cellular circuits in network-defined individual functional units is mainly associated with the regional neuronal density, while the between-functional units' connectivity strength is also influenced by the glia and synaptic components of brain tissue cellular constituents. These mechanisms lead to a rather broad distribution of resting-state functional network properties. Visual networks with the highest neuronal density (but lowest density of glial cells and synapses) exhibit the strongest coherence of the BOLD signal as well as the strongest intra-network connectivity. The Default Mode Network (DMN) is positioned near the opposite part of the spectrum with relatively low coherence of the BOLD signal but with a remarkably balanced cellular contents, enabling DMN to have a prominent role in the overall organization of the brain and hierarchy of functional networks.
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