Evidence map›Paper›PMID 34942860›Full record

ArticleBrain sciences2021

Gene-Toxicant Interactions in Gulf War Illness: Differential Effects of the

Jacqueline Vahey, Elizabeth J Gifford, Kellie J Sims, Blair Chesnut, Stephen H Boyle, Crystal Stafford, Julie Upchurch, Annjanette Stone, Saiju Pyarajan, Jimmy T Efird and 2 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Brain sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01803854 (CSP # 585 - Pilot Study), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01803854 active not recruitingnot on this map

CSP # 585 - Pilot Study: Gulf War Era Cohort and Biorepository

TypeobservationalSponsorVA Office of Research and DevelopmentRan2014 to 2026Enrolled1,275ConditionsGulf War Era Cohort
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Jacqueline VaheyCooperative Studies Program Epidemiology Center-Durham, Durham VA Medical Center, Durham VA Health Care System, Durham, NC 27705, USA.ORCID 0000-0002-0449-295X
Elizabeth J GiffordCooperative Studies Program Epidemiology Center-Durham, Durham VA Medical Center, Durham VA Health Care System, Durham, NC 27705, USA.
Kellie J SimsCooperative Studies Program Epidemiology Center-Durham, Durham VA Medical Center, Durham VA Health Care System, Durham, NC 27705, USA.
Blair ChesnutCooperative Studies Program Epidemiology Center-Durham, Durham VA Medical Center, Durham VA Health Care System, Durham, NC 27705, USA.
Stephen H BoyleCooperative Studies Program Epidemiology Center-Durham, Durham VA Medical Center, Durham VA Health Care System, Durham, NC 27705, USA.
Crystal StaffordCooperative Studies Program Epidemiology Center-Durham, Durham VA Medical Center, Durham VA Health Care System, Durham, NC 27705, USA.
Julie UpchurchCooperative Studies Program Epidemiology Center-Durham, Durham VA Medical Center, Durham VA Health Care System, Durham, NC 27705, USA.ORCID 0000-0002-2668-2535
Annjanette StonePharmacogenomics Analysis Laboratory, Research Service, Central Arkansas Veterans Healthcare System, Little Rock, AR 72205, USA.
Saiju PyarajanMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA 02130, USA.
Jimmy T EfirdCooperative Studies Program Epidemiology Center-Durham, Durham VA Medical Center, Durham VA Health Care System, Durham, NC 27705, USA.
Christina D WilliamsCooperative Studies Program Epidemiology Center-Durham, Durham VA Medical Center, Durham VA Health Care System, Durham, NC 27705, USA.
Elizabeth R HauserCooperative Studies Program Epidemiology Center-Durham, Durham VA Medical Center, Durham VA Health Care System, Durham, NC 27705, USA.
Durham VA Health Care System · USDuke University · USCentral Arkansas Veterans Healthcare System · USVA Boston Healthcare System · US

Funding

Duke University Department of Biostatistics and BioinformaticsUnited States Department of Veterans Affairs CSP585
6 · The paper itself

Abstract

About 25-35% of United States veterans who fought in the 1990-1991 Gulf War report several moderate or severe chronic systemic symptoms, defined as Gulf War illness (GWI). Thirty years later, there is little consensus on the causes or biological underpinnings of GWI. The Gulf War Era Cohort and Biorepository (GWECB) was designed to investigate genetic and environmental associations with GWI and consists of 1343 veterans. We investigate candidate gene-toxicant interactions that may be associated with GWI based on prior associations found in human and animal model studies, focusing on SNPs in or near

Indexed as

gene–environment interactionsGulf War illnessGWIpesticidesPON1pyridostigmine bromideveteran health

Identifiers

PMID34942860
PMCPMC8699623
OpenAlexW3216423537

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.