Evidence map›Paper›PMID 34942684›Full record

ArticleCancer research and treatment2022

Lobular Carcinoma In Situ during Preoperative Biopsy and the Rate of Upgrade.

Jeea Lee, Ga Yoon Ku, Haemin Lee, Hyung Seok Park, Ja Seung Ku, Jee Ye Kim, Seho Park, Byeong-Woo Park

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Article in Cancer research and treatment, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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0cells of the map it votes in
2citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Jeea LeeDepartment of Surgery, Yonsei University College of Medicine, Seoul, Korea.
Ga Yoon KuDepartment of Surgery, Yonsei University College of Medicine, Seoul, Korea.
Haemin LeeDepartment of Surgery, Yonsei University College of Medicine, Seoul, Korea.
Hyung Seok ParkDepartment of Surgery, Yonsei University College of Medicine, Seoul, Korea.
Ja Seung KuDepartment of Pathology, Yonsei University College of Medicine, Seoul, Korea.
Jee Ye KimDepartment of Surgery, Yonsei University College of Medicine, Seoul, Korea.
Seho ParkDepartment of Surgery, Yonsei University College of Medicine, Seoul, Korea.
Byeong-Woo ParkDepartment of Surgery, Yonsei University College of Medicine, Seoul, Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThere is a potential risk that lobular carcinoma in situ (LCIS) on preoperative biopsy might be diagnosed as ductal carcinoma in situ (DCIS) or invasive carcinoma in the final pathology. This study aimed to evaluate the rate of upgrade of LCIS on preoperative biopsy to DCIS or invasive carcinoma. MATERIALS AND

methodsData of 55 patients with LCIS on preoperative biopsy were analyzed. All patients underwent surgery between 1991 and 2016 at Severance Hospital in Seoul, Korea. We analyzed the rate of upgrade of preoperative LCIS to DCIS or invasive cancer in the final pathology. The clinicopathologic features related to the upgrade were evaluated.

resultsThe rate of upgrade of LCIS to DCIS or invasive carcinoma was 16.4% (9/55). In multivariate analysis, microcalcification and progesterone receptor expression were significantly associated with the upgrade of LCIS (p=0.023 and p=0.044, respectively).

conclusionThe current study showed a relatively high rate of upgrade of LCIS on preoperative biopsy to DCIS or invasive cancer. The presence of microcalcification and progesterone receptor expression may be potential predictors of upgradation of LCIS on preoperative biopsy. Surgical excision of the LCIS during preoperative biopsy could be a management option to identify the concealed malignancy.

Indexed as

Breast Carcinoma In SituBreast NeoplasmsCalcinosisCarcinoma in SituCarcinoma, Intraductal, NoninfiltratingCarcinoma, LobularBiopsyFemaleHumansReceptors, ProgesteroneReceptors, ProgesteroneBreast carcinoma in situBreast neoplasmsCore needle biopsyLobular carcinoma in situSurgical diagnostic technics

Identifiers

PMID34942684
PMCPMC9582467

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.