ArticleJournal of cognitive neuroscience2022
Revisiting the Role of the Medial Temporal Lobe in Motor Learning.
Article in Journal of cognitive neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Neural dynamics underlying minute-timescale persistent behaviour in the human brain.Nature human behaviour · 2026Article
- Temporal interference stimulation for deep brain neuromodulation in humans.Nature biomedical engineering · 2026Review
- Hippocampal-entorhinal cognitive maps and cortical motor system represent action plans and their outcomes.Nature communications · 2025Article
- The role of training variability for model-based and model-free learning of an arbitrary visuomotor mapping.PLoS computational biology · 2024Article
- Review
- Early-Stage Alzheimer's Disease Affects Fast But Not Slow Adaptive Processes in Motor Learning.eNeuro · 2024Article
- Maintenance of Procedural Motor Memory across Brief Rest Periods Requires the Hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Reinforcement Learning during Locomotion.eNeuro · 2024Article
- The effects of football juggling learning on executive function and brain functional connectivity.Frontiers in human neuroscience · 2024Article
- Whole-brain dynamics of human sensorimotor adaptation.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Abstract task representations for inference and control.Trends in cognitive sciences · 2022Review
- Reward timing matters in motor learning.iScience · 2022Article
- Implicit sensorimotor adaptation is preserved in Parkinson's disease.Brain communications · 2022Article
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Authors and funding
4 authors.
Funding
Abstract
Classic taxonomies of memory distinguish explicit and implicit memory systems, placing motor skills squarely in the latter branch. This assertion is in part a consequence of foundational discoveries showing significant motor learning in amnesics. Those findings suggest that declarative memory processes in the medial temporal lobe (MTL) do not contribute to motor learning. Here, we revisit this issue, testing an individual (L. S. J.) with severe MTL damage on four motor learning tasks and comparing her performance to age-matched controls. Consistent with previous findings in amnesics, we observed that L. S. J. could improve motor performance despite having significantly impaired declarative memory. However, she tended to perform poorly relative to age-matched controls, with deficits apparently related to flexible action selection. Further supporting an action selection deficit, L. S. J. fully failed to learn a task that required the acquisition of arbitrary action-outcome associations. We thus propose a modest revision to the classic taxonomic model: Although MTL-dependent memory processes are not necessary for some motor learning to occur, they play a significant role in the acquisition, implementation, and retrieval of action selection strategies. These findings have implications for our understanding of the neural correlates of motor learning, the psychological mechanisms of skill, and the theory of multiple memory systems.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.