ArticleJournal of cognitive neuroscience2022
Differential Developmental Associations of Material Hardship Exposure and Adolescent Amygdala-Prefrontal Cortex White Matter Connectivity.
Article in Journal of cognitive neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Effects of light therapy on amygdala connectivity and serotoninergic system in young adults with subthreshold depression.Dialogues in clinical neuroscience · 2025Trial
- Childhood Material Hardship Linked to Adolescent Neurocognition: A Computational Modeling Approach.Developmental science · 2026Article
- A Systematic Evaluation of the Performance of Multiple Brain Age Algorithms in Two Cohorts of Youth.Human brain mapping · 2026Article
- Social Determinants of Health, the developing brain, and risk and resilience for psychopathology.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Childhood adversity and adolescent mental health: Examining cumulative and specificity effects across contexts and developmental timing.Development and psychopathology · 2025Article
- Association Between Neighborhood Opportunity, Cognitive Function, and Brain Structure in Youths.Biological psychiatry global open science · 2025Article
- Multivariate Links Between the Developmental Timing of Adversity Exposure and White Matter Tract Connectivity in Adulthood.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Smaller Subcortical Volume in Reward Processing Regions Precedes Weight Gain in Youth With High Financial Adversity: Findings From the Adolescent Brain Cognitive Development Study.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2025Article
- Whole-brain white matter variation across childhood environments.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Increasing diversity in neuroimaging research: Participant-driven recommendations from a qualitative study of an under-represented sample.Developmental cognitive neuroscience · 2024Article
- Mother-child closeness and adolescent structural neural networks: a prospective longitudinal study of low-income families.Social cognitive and affective neuroscience · 2024Article
- The neurophysiological consequences of racism-related stressors in Black Americans.Neuroscience and biobehavioral reviews · 2024Review
- Positive or negative environmental modulations on human brain development: the morpho-functional outcomes of music training or stress.Frontiers in neuroscience · 2023Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
Accumulating literature has linked poverty to brain structure and function, particularly in affective neural regions; however, few studies have examined associations with structural connections or the importance of developmental timing of exposure. Moreover, prior neuroimaging studies have not used a proximal measure of poverty (i.e., material hardship, which assesses food, housing, and medical insecurity) to capture the lived experience of growing up in harsh economic conditions. The present investigation addressed these gaps collectively by examining the associations between material hardship (ages 1, 3, 5, 9, and 15 years) and white matter connectivity of frontolimbic structures (age 15 years) in a low-income sample. We applied probabilistic tractography to diffusion imaging data collected from 194 adolescents. Results showed that material hardship related to amygdala-prefrontal, but not hippocampus-prefrontal or hippocampus-amygdala, white matter connectivity. Specifically, hardship during middle childhood (ages 5 and 9 years) was associated with greater connectivity between the amygdala and dorsomedial pFC, whereas hardship during adolescence (age 15 years) was related to reduced amygdala-orbitofrontal (OFC) and greater amygdala-subgenual ACC connectivity. Growth curve analyses showed that greater increases of hardship across time were associated with both greater (amygdala-subgenual ACC) and reduced (amygdala-OFC) white matter connectivity. Furthermore, these effects remained above and beyond other types of adversity, and greater hardship and decreased amygdala-OFC connectivity were related to increased anxiety and depressive symptoms. Results demonstrate that the associations between material hardship and white matter connections differ across key prefrontal regions and developmental periods, providing support for potential windows of plasticity for structural circuits that support emotion processing.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.