ArticleNeuroImage2022
Effect sizes and test-retest reliability of the fMRI-based neurologic pain signature.
Article in NeuroImage, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05986513 (Investigating Brain Abnormalities in People With Knee Osteoarthritis Using MRI), which is not on this map. Cited by 39 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigating Brain Abnormalities in People With Knee Osteoarthritis Using MRI: a Nociplastic Pain Mechanism Based Assessment
Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analytic evidence for distinct neural correlates of conditioned versus verbally induced placebo analgesia.Nature communications · 2026Pooled it
- Auditory Hyperresponsivity in Chronic Back Pain: A Randomized Controlled Trial of Pain Reprocessing Therapy.Annals of neurology · 2026Trial
- Ketamine-induced analgesia and dissociation show distinct behavioral and neural correlates.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- The functional neurobiology of dispositions towards negative emotions.Nature communications · 2026Article
- Precision Imaging for Intraindividual Investigation of the Reward Response.Human brain mapping · 2026Article
- Implementation of support vector machines to classify abnormal neuronal response during emotion regulation at an individual level in patients with newly diagnosed bipolar disorder - and its association with subsequent functional changes and mood episodes.Psychological medicine · 2025Article
- Structured Neural Variability from Repeated Naturalistic Video Watching Experiences.bioRxiv : the preprint server for biology · 2025Article
- Precision Imaging for Intraindividual Investigation of the Reward Response.bioRxiv : the preprint server for biology · 2025Article
- Article
- Complications of applying approximate entropy to heart rate variability to locate optimal complexity in children with attention deficit hyperactivity disorder.European journal of applied physiology · 2025Article
- The functional neurobiology of negative affective traits across regions, networks, signatures, and a machine learning multiverse.bioRxiv : the preprint server for biology · 2025Article
- Intermittent Fasting Enhances Motor Coordination Through Myelin Preservation in Aged Mice.Aging cell · 2025Article
- Expectation generation and its effect on subsequent pain and visual perception.PLoS computational biology · 2025Article
- Nature exposure induces analgesic effects by acting on nociception-related neural processing.Nature communications · 2025Article
- Using Machine Learning to Determine a Functional Classifier of Retaliation and Its Association With Aggression.JAACAP open · 2025Article
- Enhancing task fMRI individual difference research with neural signatures.medRxiv : the preprint server for health sciences · 2025Article
- Placebo treatment affects brain systems related to affective and cognitive processes, but not nociceptive pain.Nature communications · 2024Article
- A neurofunctional signature of subjective disgust generalizes to oral distaste and socio-moral contexts.Nature human behaviour · 2024Article
- Divergent association between pain intensity and resting-state fMRI-based brain entropy in different age groups.Journal of neuroscience research · 2024Article
- Reliability of task-based fMRI in the dorsal horn of the human spinal cord.Imaging neuroscience (Cambridge, Mass.) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
Identifying biomarkers that predict mental states with large effect sizes and high test-retest reliability is a growing priority for fMRI research. We examined a well-established multivariate brain measure that tracks pain induced by nociceptive input, the Neurologic Pain Signature (NPS). In N = 295 participants across eight studies, NPS responses showed a very large effect size in predicting within-person single-trial pain reports (d = 1.45) and medium effect size in predicting individual differences in pain reports (d = 0.49). The NPS showed excellent short-term (within-day) test-retest reliability (ICC = 0.84, with average 69.5 trials/person). Reliability scaled with the number of trials within-person, with ≥60 trials required for excellent test-retest reliability. Reliability was tested in two additional studies across 5-day (N = 29, ICC = 0.74, 30 trials/person) and 1-month (N = 40, ICC = 0.46, 5 trials/person) test-retest intervals. The combination of strong within-person correlations and only modest between-person correlations between the NPS and pain reports indicate that the two measures have different sources of between-person variance. The NPS is not a surrogate for individual differences in pain reports but can serve as a reliable measure of pain-related physiology and mechanistic target for interventions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.