Evidence map›Paper›PMID 34942287›Full record

ArticleBiological psychology2022

Interoception as modeling, allostasis as control.

Eli Sennesh, Jordan Theriault, Dana Brooks, Jan-Willem van de Meent, Lisa Feldman Barrett, Karen S Quigley

Open access · greenAbstract read
In one paragraph

Article in Biological psychology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 4 pooled it
14.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 4 syntheses or guidelines pooled it, 100 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Article
  7. Categorization is 'baked' into the brain.Nature reviews. Neuroscience · 2026
    Review
  8. Article
  9. Poststroke Fatigue: An Overlooked Barrier to Functional Recovery.Journal of the American Heart Association · 2026
    Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. The interoceptive origin of reinforcement learning.Trends in cognitive sciences · 2025
    Review
  17. Metacognitive Feelings: A Predictive-Processing Perspective.Perspectives on psychological science : a journal of the Association for Psychological Science · 2025
    Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Eli SenneshNortheastern University, Boston, MA , United States. Electronic address: sennesh.e@northeastern.edu.
Jordan TheriaultNortheastern University, Boston, MA , United States.
Dana BrooksNortheastern University, Boston, MA , United States.
Jan-Willem van de MeentNortheastern University, Boston, MA , United States.
Lisa Feldman BarrettNortheastern University, Boston, MA , United States.
Karen S QuigleyNortheastern University, Boston, MA , United States.
Northeastern University · US

Funding

Affect regulation and Beta Amyloid: Maturational Factors in Aging and Age-Related PathologyR01MH113234 · NIMH · NORTHEASTERN UNIVERSITY · PI DICKERSON, BRADFORD C, ISAACOWITZ, DEREK M · 2017 to 2021
$4.2M
Fundamental subcortical mechanisms of affective processingU01CA193632 · NCI · NORTHEASTERN UNIVERSITY · PI BARRETT, LISA FELDMAN, SATPUTE, AJAY · 2016 to 2020
$3.0M
NCI NIH HHS U01 CA193632NIMH NIH HHS R01 MH113234
6 · The paper itself

Abstract

The brain regulates the body by anticipating its needs and attempting to meet them before they arise - a process called allostasis. Allostasis requires a model of the changing sensory conditions within the body, a process called interoception. In this paper, we examine how interoception may provide performance feedback for allostasis. We suggest studying allostasis in terms of control theory, reviewing control theory's applications to related issues in physiology, motor control, and decision making. We synthesize these by relating them to the important properties of allostatic regulation as a control problem. We then sketch a novel formalism for how the brain might perform allostatic control of the viscera by analogy to skeletomotor control, including a mathematical view on how interoception acts as performance feedback for allostasis. Finally, we suggest ways to test implications of our hypotheses.

Indexed as

AllostasisInteroceptionBrainHumansAllostasisInteroceptionPredictive processing

Identifiers

PMID34942287
PMCPMC9270659
OpenAlexW4200245063

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.