Evidence map›Paper›PMID 34942232›Full record

ReviewFrontiers in neuroendocrinology2022

A neural circuit perspective on brain aromatase.

Jeremy A Spool, Joseph F Bergan, Luke Remage-Healey

Open access · greenAbstract readReview
In one paragraph

Review in Frontiers in neuroendocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
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  7. Social memory in female mice is rapidly modulated by 17β-estradiol through ERK and Akt modulation of synapse formation.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jeremy A SpoolCenter for Neuroendocrine Studies, Neuroscience and Behavior Graduate Program, University of Massachusetts, Amherst, MA 01003, United States.
Joseph F BerganCenter for Neuroendocrine Studies, Neuroscience and Behavior Graduate Program, University of Massachusetts, Amherst, MA 01003, United States.
Luke Remage-HealeyCenter for Neuroendocrine Studies, Neuroscience and Behavior Graduate Program, University of Massachusetts, Amherst, MA 01003, United States. Electronic address: lremageh@umass.edu.
University of Massachusetts Amherst · US

Funding

Rapid Estrogen Signaling in Brain Circuits that Guide Complex BehaviorR01NS082179 · NINDS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI LUKE R REMAGE-HEALEY · 2014 to 2026
$3.8M
Synaptic contributions to sexually dimorphic circuit architectureR01MH115094 · NIMH · UNIVERSITY OF MASSACHUSETTS AMHERST · PI BERGAN, JOSEPH FOSSLAND · 2019 to 2023
$2.0M
Characterizing a Circuit Linking Auditory Cortical Systems and the Social Behavior NetworkF32DC018508 · NIDCD · UNIVERSITY OF MASSACHUSETTS AMHERST · PI SPOOL, JEREMY · 2019 to 2022
$183k
NIDCD NIH HHS F32 DC018508NIMH NIH HHS R01 MH115094NINDS NIH HHS R01 NS082179
6 · The paper itself

Abstract

This review explores the role of aromatase in the brain as illuminated by a set of conserved network-level connections identified in several vertebrate taxa. Aromatase-expressing neurons are neurochemically heterogeneous but the brain regions in which they are found are highly-conserved across the vertebrate lineage. During development, aromatase neurons have a prominent role in sexual differentiation of the brain and resultant sex differences in behavior and human brain diseases. Drawing on literature primarily from birds and rodents, we delineate brain regions that express aromatase and that are strongly interconnected, and suggest that, in many species, aromatase expression essentially defines the Social Behavior Network. Moreover, in several cases the inputs to and outputs from this core Social Behavior Network also express aromatase. Recent advances in molecular and genetic tools for neuroscience now enable in-depth and taxonomically diverse studies of the function of aromatase at the neural circuit level.

Indexed as

AromataseBrainAnimalsFemaleMaleNeuronsSex CharacteristicsSocial BehaviorAromataseAromatase inhibitorAuditoryCognitionEstrogensEvolutionLearningOlfactionSex differenceSocial decision making networkSynapsesSystems neuroscience

Identifiers

PMID34942232
PMCPMC9667830
OpenAlexW4200229324

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.