Evidence map›Paper›PMID 34942156›Full record

ArticleJornal de pediatria

Rhinoviruses as critical agents in severe bronchiolitis in infants.

Juliana Cristina Santiago Bastos, Paulo Vitor Marques Simas, Leonardo Cardia Caserta, Alfonso Eduardo Alvarez Bragunde, Fernando Augusto de Lima Marson, Matheus Cavalheiro Martini, Marina Aiello Padilla, José Dirceu Ribeiro, Márcia Mercês Aparecida Bianchi Dos Santos, Clarice Weis Arns

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Jornal de pediatria. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 1 institution in 3 countries.

Juliana Cristina Santiago BastosUniversidade Estadual de Campinas (UNICAMP), Instituto de Biologia, Departamento de Genética, Evolução, Microbiologia e Imunologia, Laboratório de Virologia Animal, Campinas, SP, Brazil.
Paulo Vitor Marques SimasUniversidade Estadual de Campinas (UNICAMP), Instituto de Biologia, Departamento de Genética, Evolução, Microbiologia e Imunologia, Laboratório de Virologia Animal, Campinas, SP, Brazil; The National University of San Marcos, Veterinary School, Laboratory of Avian Pathology, Lima, Peru.
Leonardo Cardia CasertaUniversidade Estadual de Campinas (UNICAMP), Instituto de Biologia, Departamento de Genética, Evolução, Microbiologia e Imunologia, Laboratório de Virologia Animal, Campinas, SP, Brazil; Cornell University, College of Veterinary Medicine, Department of Population Medicine and Diagnostic Sciences, Ithaca, United States.
Alfonso Eduardo Alvarez BragundeUniversidade Estadual de Campinas (UNICAMP), Faculdade de Ciências Médicas, Departamento de Pediatria, Campinas, SP, Brazil.
Fernando Augusto de Lima MarsonUniversidade Estadual de Campinas (UNICAMP), Faculdade de Ciências Médicas, Departamento de Pediatria, Campinas, SP, Brazil.
Matheus Cavalheiro MartiniUniversidade Estadual de Campinas (UNICAMP), Instituto de Biologia, Departamento de Genética, Evolução, Microbiologia e Imunologia, Laboratório de Virologia Animal, Campinas, SP, Brazil.
Marina Aiello PadillaUniversidade Estadual de Campinas (UNICAMP), Instituto de Biologia, Departamento de Genética, Evolução, Microbiologia e Imunologia, Laboratório de Virologia Animal, Campinas, SP, Brazil.
José Dirceu RibeiroUniversidade Estadual de Campinas (UNICAMP), Faculdade de Ciências Médicas, Departamento de Pediatria, Campinas, SP, Brazil.
Márcia Mercês Aparecida Bianchi Dos SantosUniversidade Estadual de Campinas (UNICAMP), Instituto de Biologia, Departamento de Genética, Evolução, Microbiologia e Imunologia, Laboratório de Virologia Animal, Campinas, SP, Brazil.
Clarice Weis ArnsUniversidade Estadual de Campinas (UNICAMP), Instituto de Biologia, Departamento de Genética, Evolução, Microbiologia e Imunologia, Laboratório de Virologia Animal, Campinas, SP, Brazil. Electronic address: clarns@gmail.com.
Universidade Estadual de Campinas (UNICAMP) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo detect RSV or other thirteen respiratory viruses as possible causer agent of bronchiolitis in infants.

methodThis is an epidemiological analytical study, conducted using a nasopharyngeal aspirate of 173 hospitalized children younger than two years old with severe bronchiolitis in three hospitals in the Campinas Metropolitan Region (CMR) during 2013-14. The data was statically evaluated by Pearson's chi-squared test with statistical significance of 0.05 and 95% confidence level.

resultsAs expected, the most prevalent viruses detected were RSV A and B in 47% and 16% of the samples, respectively. However, almost a third of severe bronchiolitis cases there were no detection of RSV, and the viruses more commonly detected were rhinoviruses, which were identified in almost a quarter of all positive samples for at least a viral agent.

conclusionsAlthough nothing could be concluded from the disease severity and clinical-epidemiological data, the present study's results indicate that severe bronchiolitis is not always related to RSV infections in children younger than two years old, and the rhinoviruses were more prevalent in these cases. These findings reinforce the need to carry out a viral diagnosis in the hospital emergency would be very appropriate for all cases of respiratory infections in children, even for diseases in which the primary etiological agent seems to be well known.

Indexed as

BronchiolitisBronchiolitis, ViralRespiratory Syncytial Virus InfectionsRespiratory Tract InfectionsChildChild, PreschoolHumansInfantRhinovirusSeverity of Illness IndexBronchiolitisEpidemiologyRespiratory syncytial virusRhinovirus

Identifiers

PMID34942156
PMCPMC9432127
OpenAlexW4200295721

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.