Evidence map›Paper›PMID 34942115›Full record

ArticleDevelopmental cell2022

chinmo-mutant spermatogonial stem cells cause mitotic drive by evicting non-mutant neighbors from the niche.

Chen-Yuan Tseng, Michael Burel, Michael Cammer, Sneh Harsh, Maria Sol Flaherty, Stefan Baumgartner, Erika A Bach

Open access · greenAbstract read
In one paragraph

Article in Developmental cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Stem cell competition.Current topics in developmental biology · 2026
    Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. An expanded view of cell competition.Development (Cambridge, England) · 2024
    Review
  11. Review
  12. Article
  13. Article
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  15. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 3 countries.

Chen-Yuan TsengDepartment of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA.
Michael BurelDepartment of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA.
Michael CammerDART Microscopy Laboratory, NYU Langone Health, New York, NY 10016, USA.
Sneh HarshDepartment of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA.
Maria Sol FlahertyDepartment of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA.
Stefan BaumgartnerDepartment of Experimental Medical Sciences, Lunds Universitet, 22184 Lund, Sweden; Department of Biology, University of Konstanz, 78467 Konstanz, Germany.
Erika A BachDepartment of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA; Helen L. and Martin S. Kimmel Center for Stem Cell Biology, NYU Grossman School of Medicine, New York, NY 10016, USA. Electronic address: erika.bach@nyu.edu.
New York University · USUniversity of Konstanz · DE

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ANIRBAN MAITRA · 1985 to 2026
$83.1M
FLYBASE: A DROSOPHILA RELATIONAL DATABASEP41HG000739 · NHGRI · HARVARD UNIVERSITY · PI GELBART, WILLIAM MARTIN · 1992 to 2014
$56.6M
Resource Project CoreU41HG000739 · NHGRI · HARVARD UNIVERSITY · PI PERRIMON, NORBERT · 2014 to 2022
$32.3M
Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
Eludicating the Molecular Mechanisms That Regulate Stem Cell Numbers in VivoR01GM085075 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BACH, ERIKA A · 2009 to 2023
$4.3M
JAK/STAT PATHWAY CONTROL OF CELL COMPETITION DURING DEVELOPMENT.R03HD069576 · NICHD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BACH, ERIKA A · 2012 to 2014
$249k
Uncovering mechanisms controlling germline stem cell competitionR03HD090422 · NICHD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BACH, ERIKA A · 2017 to 2018
$170k
NCI NIH HHS P30 CA016087NHGRI NIH HHS P41 HG000739NHGRI NIH HHS U41 HG000739NICHD NIH HHS R03 HD069576NICHD NIH HHS R03 HD090422NIGMS NIH HHS R01 GM085075NIH HHS P40 OD018537
6 · The paper itself

Abstract

Niches maintain a finite pool of stem cells via restricted space and short-range signals. Stem cells compete for limited niche resources, but the mechanisms regulating competition are poorly understood. Using the Drosophila testis model, we show that germline stem cells (GSCs) lacking the transcription factor Chinmo gain a competitive advantage for niche access. Surprisingly, chinmo

Indexed as

Adult Germline Stem CellsAnimalsCell DifferentiationDrosophila melanogasterDrosophila ProteinsExtracellular MatrixGene ExpressionGene Expression Regulation, DevelopmentalGerm CellsHeparan Sulfate ProteoglycansMaleNerve Tissue ProteinsSignal TransductionStem Cell NicheTestisTranscription FactorsChinmo protein, DrosophilaDrosophila ProteinsHeparan Sulfate ProteoglycansNerve Tissue ProteinsperlecanTranscription Factorsagingbiased inheritancechinmocompetitionDrosophilaDystroglycangermline stem cellnichePerlecantestis

Identifiers

PMID34942115
PMCPMC8752517
OpenAlexW4200145604

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.