ArticleAmerican journal of ophthalmology2022
Ganglion Cell Complex: The Optimal Measure for Detection of Structural Progression in the Macula.
Article in American journal of ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed.
- Sectoral analysis of macular inner retinal layers and diagnostic performance in early pseudoexfoliation glaucoma.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Subtype-Specific Macular Vascular Signatures in Primary Open-Angle, Pseudoexfoliative, and Normal-Tension Glaucoma: OCT Angiography Study.Medicina (Kaunas, Lithuania) · 2026Article
- An Artificial Intelligence-Based Prognostic Model for Prediction of Functional Glaucoma Progression From Clinical and Structural Data.American journal of ophthalmology · 2026Article
- A Bayesian Hierarchical Longitudinal Model for Estimation of Central Visual Field Rates of Change in Glaucoma.Translational vision science & technology · 2025Article
- A SPATIALLY VARYING HIERARCHICAL RANDOM EFFECTS MODEL FOR LONGITUDINAL MACULAR STRUCTURAL DATA IN GLAUCOMA PATIENTS.The annals of applied statistics · 2024Article
- Progressive Thickening of Retinal Nerve Fiber and Ganglion Cell Complex Layers Following SDM Laser Vision Protection Therapy in Open-Angle Glaucoma.Ophthalmology and therapy · 2024Article
- Racial-ethnic disparities in concurrent rates of peripapillary & macular OCT parameters among a large glaucomatous clinical population.Eye (London, England) · 2024Article
- A Bayesian Hierarchical Spatial Longitudinal Model Improves Estimation of Local Macular Rates of Change in Glaucomatous Eyes.Translational vision science & technology · 2024Article
- Detection of Early Glaucomatous Damage: Performance of Summary Statistics From Optical Coherence Tomography and Perimetry.Translational vision science & technology · 2022Article
- Effect of idiopathic epiretinal membrane on macular ganglion cell complex measurement in eyes with glaucoma.Frontiers in medicine · 2022Article
- A Joint Bayesian Longitudinal Model for Macular Structure-Function Correlations in Glaucoma.Ophthalmology scienceArticle
- Comparison of Ganglion Cell Layer and Ganglion Cell/Inner Plexiform Layer Measures for Detection of Early Glaucoma.Ophthalmology. GlaucomaArticle
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10 authors.
Funding
Abstract
purposeTo test the hypothesis that macular ganglion cell complex (GCC) thickness from optical coherence tomography (OCT) provides a stronger change signal regardless of glaucoma severity compared with other macular measures.
designProspective cohort study.
methodsEyes were from 112 patients with moderate to severe glaucoma at baseline from a tertiary glaucoma center. In each 3° × 3° macular superpixel, a hierarchical Bayesian random intercept and slope model with random residual variance was fit to longitudinal full macular thickness (FMT), outer retina layers, GCC, ganglion cell-inner plexiform layer (GCIPL), and ganglion cell layer (GCL) measurements. We estimated population- and individual-level slopes and intercepts. Proportions of substantial worsening and improving superpixel slopes were compared between layers and in superpixels with mild to moderate vs severe damage (total deviation of corresponding visual field location ≥ -8 vs < -8 dB).
resultsMean (SD) follow-up time and baseline 10-2 visual field mean deviation were 3.6 (0.4) years and -8.9 (5.9) dB, respectively. FMT displayed the highest proportion of significant negative slopes (1932/3519 [54.9%]), followed by GCC (1286/3519 [36.5%]), outer retina layers (1254/3519 [35.6%]), (GCIPL) (1075/3518 [30.6%]), and (GCL) (698/3518 [19.8%]). Inner macular measures detected less worsening in the severe glaucoma group; yet GCC (223/985 [22.6%]) identified the highest proportion (GCIPL: 183/985 [18.6%]; GCL: 106/985 [10.8%]). Proportions of positive rates were small and comparable among all measures.
conclusionsGCC is the optimal macular measure for detection of structural change in eyes with moderate to severe glaucoma. Although a higher proportion of worsening superpixels was observed for FMT, a large portion of FMT change could be attributed to changes in outer retina layers.
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