Evidence map›Paper›PMID 34942106›Full record

Trial reportAmerican journal of ophthalmology2022

Community Health Workers for Prevention of Corneal Ulcers in South India: A Cluster-Randomized Trial.

Muthiah Srinivasan, Thulasiraj Ravilla, Valaguru Vijayakumar, Devanesam Yesunesan, Iswarya Mani, John P Whitcher, Catherine E Oldenburg, Kieran S O'Brien, Thomas M Lietman, Jeremy D Keenan

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in American journal of ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02284698 (Corneal Ulcer Prevention Through Health Education), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02284698 unknown statusnot on this map

Corneal Ulcer Prevention Through Health Education

TypeobservationalSponsorAravind Eye Care SystemRan2014 to 2017Enrolled98,207ConditionsCorneal UlcerArmsHealth Education
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Muthiah SrinivasanFrom the Department of Cornea and Refractive Surgery (M.S), Aravind Eye Care System, Madurai, India.
Thulasiraj RavillaLions Aravind Institute of Community Ophthalmology (T.R., V.V., D.Y.), Aravind Eye Care System, Madurai, India.
Valaguru VijayakumarLions Aravind Institute of Community Ophthalmology (T.R., V.V., D.Y.), Aravind Eye Care System, Madurai, India.
Devanesam YesunesanLions Aravind Institute of Community Ophthalmology (T.R., V.V., D.Y.), Aravind Eye Care System, Madurai, India.
Iswarya ManiDepartment of Biostatistics (I.M.), Aravind Eye Care System, Madurai, India.
John P WhitcherFrancis I. Proctor Foundation (J.P.W., C.E.O., K.S.O., T.M.L., J.D.K.), University of California San Francisco, San Francisco, California, USA; Francis I Proctor Foundation (J.P.W., C.E.O., T.M.L., J.D.K.), University of California San Francisco, San Francisco, California, USA.
Catherine E OldenburgFrancis I. Proctor Foundation (J.P.W., C.E.O., K.S.O., T.M.L., J.D.K.), University of California San Francisco, San Francisco, California, USA; Francis I Proctor Foundation (J.P.W., C.E.O., T.M.L., J.D.K.), University of California San Francisco, San Francisco, California, USA; Department of Epidemiology and Biostatistics (C.E.O., T.M.L), University of California San Francisco, San Francisco, California, USA.
Kieran S O'BrienFrancis I. Proctor Foundation (J.P.W., C.E.O., K.S.O., T.M.L., J.D.K.), University of California San Francisco, San Francisco, California, USA.
Thomas M LietmanFrancis I. Proctor Foundation (J.P.W., C.E.O., K.S.O., T.M.L., J.D.K.), University of California San Francisco, San Francisco, California, USA; Francis I Proctor Foundation (J.P.W., C.E.O., T.M.L., J.D.K.), University of California San Francisco, San Francisco, California, USA; Department of Epidemiology and Biostatistics (C.E.O., T.M.L), University of California San Francisco, San Francisco, California, USA; and the Institute for Global Health Sciences (T.M.L.), University of California San Francisco, San Francisco, California, USA.
Jeremy D KeenanFrancis I. Proctor Foundation (J.P.W., C.E.O., K.S.O., T.M.L., J.D.K.), University of California San Francisco, San Francisco, California, USA; Francis I Proctor Foundation (J.P.W., C.E.O., T.M.L., J.D.K.), University of California San Francisco, San Francisco, California, USA. Electronic address: jeremy.keenan@ucsf.edu.
Aravind Eye Hospital · INUniversity of California, San Francisco · US

Funding

Village Integrated Eye Workers TrialU10EY022880 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LIETMAN, THOMAS M · 2013 to 2017
$2.3M
NEI NIH HHS U10 EY022880
6 · The paper itself

Abstract

purposeTo determine whether a community health worker (CHW) program increases referrals to local eye care providers and ultimately reduces the incidence of corneal ulcers.

designCluster-randomized trial performed from 2014 to 2017 in rural South India.

methodsThis was a community-based study that included all inhabitants of 42 rural South Indian communities. CHWs were trained to diagnose corneal abrasions and assist participants in seeking care at a local vision center. Given the nature of the intervention, the trial was not masked. The main outcome measure was incident corneal ulcer, defined as an active infiltrate or evidence of a new opacity, as assessed by means of penlight examination during an annual door-to-door census.

resultsTwenty-one study clusters were randomized to the CHW intervention and 21 to no intervention. Vision centers diagnosed 195 corneal abrasions from the intervention clusters during the 2-year study (rate, 223 per 100,000 person-years; 95% CI, 28-1743) and 62 from the control clusters (rate, 62 per 100,000 person-years; 95% CI, 8-496; incidence rate ratio, 3.57; 95% CI, 2.01-6.35; P < .001). The estimated incidence of corneal ulceration during the study period was 60 per 100,000 person-years (95% CI, 25-141) in the intervention group and 32 per 100,000 person-years (95% CI, 13-80) in the control group (incidence rate ratio, 1.86; 95% CI, 0.5-6.4; P = .32).

conclusionsA CHW program resulted in 3.5 times more referrals to local eye care providers for corneal abrasions, but no difference could be detected in the incidence of corneal ulceration. CHW programs provide a mechanism for increasing referrals to eye hospitals.

trial registrationClinicalTrials.gov ID: NCT02284698.

Indexed as

Corneal InjuriesCorneal UlcerCommunity Health WorkersHumansIndiaRural Population

Identifiers

PMID34942106
PMCPMC10276527
OpenAlexW4200439890

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.