Evidence map›Paper›PMID 34941815›Full record

ArticleVeterinary sciences2021

Locomotor Behavior Analysis in Spinal Cord Injured

Anand Paramasivam, Suresh Mickymaray, Saikarthik Jayakumar, Mathew Jeraud, Periasamy Perumal, Abdullah Alassaf, Abdullah Abdulrahman Aljabr, Sridevi Dasarathy, Suresh Babu Rangasamy

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 59% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Anand ParamasivamDepartment of Basic Medical Sciences, College of Dentistry, Majmaah University, Al-Majmaah 11952, Saudi Arabia.ORCID 0000-0002-2626-6910
Suresh MickymarayDepartment of Biology, College of Science, Majmaah University, Majmaah 11952, Saudi Arabia.
Saikarthik JayakumarDepartment of Basic Medical Sciences, College of Dentistry, Majmaah University, Al-Majmaah 11952, Saudi Arabia.ORCID 0000-0002-9803-270X
Mathew JeraudDepartment of Physiology, Dr. ALM PGIBMS, University of Madras, Chennai 600113, India.
Periasamy PerumalDepartment of Physiology, Dr. ALM PGIBMS, University of Madras, Chennai 600113, India.
Abdullah AlassafDepartment of Preventive Dental Sciences, College of Dentistry, Majmaah University, Majmaah 11952, Saudi Arabia.
Abdullah Abdulrahman AljabrDepartment of Medical Education, College of Dentistry, Majmaah University, Majmaah 11952, Saudi Arabia.ORCID 0000-0003-3944-0700
Sridevi DasarathyDepartment of Neurological Sciences, Rush University Medical Centre, Chicago, IL 60612, USA.
Suresh Babu RangasamyDepartment of Physiology, Dr. ALM PGIBMS, University of Madras, Chennai 600113, India.
Majmaah University · SARush University Medical Center · USUniversity of Madras · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPrimate animal models are being utilized to explore novel therapies for spinal cord injuries. This study aimed to evaluate the efficiency of the transplantation of predegenerated nerve segments in unilateral spinal cord-hemisected bonnet monkeys' ( MATERIALS AND

methodsThe bonnet monkeys were initially trained to walk in a bipedal motion on grid and staircase runways. In one group of trained monkeys, surgical hemisection was made in the spinal cord at the T12-L1 level. In the other group, hemisection was induced in the spinal cord, and the ulnar nerve was also transected at the same time (transplant group). After one week, the hemisected cavity was reopened and implanted with predegenerated ulnar nerve segments obtained from the same animal of the transplant group.

resultsAll the operated monkeys showed significant deficits in locomotion on runways at the early postoperative period. The walking ability of operated monkeys was found to be gradually improved, and they recovered nearer to preoperative level at the fourth postoperative month, and there were no marked differences.

conclusionThe results demonstrate that there were no significant improvements in the locomotion of monkeys on runways after the delayed grafting of nerve segments until one year later. The failure of the predegenerated nerve graft as a possible therapeutic strategy to improve the locomotion of monkeys may be due to a number of factors set in motion by trauma, which could possibly prevent the qualities of regeneration. The exact reason for this ineffectiveness of predegenerated nerve segments and their underlying mechanism is not known.

Indexed as

locomotor recoveryMacaca radiatapredegenerated nerve transplantationspinal cord hemisection

Identifiers

PMID34941815
PMCPMC8707676
OpenAlexW3216671895

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.