Evidence map›Paper›PMID 34941741›Full record

ArticleToxins2021

Pharmacological Investigation of CC-LAAO, an L-Amino Acid Oxidase from

Zaineb Abdelkafi-Koubaa, Ines ELBini-Dhouib, Soumaya Souid, Jed Jebali, Raoudha Doghri, Najet Srairi-Abid, Khadija Essafi-Benkhadir, Olivier Micheau, Naziha Marrakchi

Open access · goldAbstract read
In one paragraph

Article in Toxins, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
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  5. Cobra (Journal of biosciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Zaineb Abdelkafi-KoubaaLaboratoire des Biomolécules, Venins et Applications Théranostiques (LR20IPT01), Institut Pasteur de Tunis, Université de Tunis El Manar, Tunis 1002, Tunisia.
Ines ELBini-DhouibLaboratoire des Biomolécules, Venins et Applications Théranostiques (LR20IPT01), Institut Pasteur de Tunis, Université de Tunis El Manar, Tunis 1002, Tunisia.ORCID 0000-0002-2224-0211
Soumaya SouidLaboratoire d'Epidémiologie Moléculaire et de Pathologie Expérimentale (LR16IPT04), Institut Pasteur de Tunis, Université de Tunis El Manar, Tunis 1002, Tunisia.
Jed JebaliLaboratoire des Biomolécules, Venins et Applications Théranostiques (LR20IPT01), Institut Pasteur de Tunis, Université de Tunis El Manar, Tunis 1002, Tunisia.
Raoudha DoghriDépartement d'Anatomie Pathologique, Institut Salah Azaiez, Bab Saadoun, Tunis 1006, Tunisia.
Najet Srairi-AbidLaboratoire des Biomolécules, Venins et Applications Théranostiques (LR20IPT01), Institut Pasteur de Tunis, Université de Tunis El Manar, Tunis 1002, Tunisia.
Khadija Essafi-BenkhadirLaboratoire d'Epidémiologie Moléculaire et de Pathologie Expérimentale (LR16IPT04), Institut Pasteur de Tunis, Université de Tunis El Manar, Tunis 1002, Tunisia.ORCID 0000-0003-1371-1963
Olivier MicheauLipides Nutrition Cancer, INSERM-UMR 1231, Université de Bourgogne Franche-Comté, UFR Science de Santé, 7 Bd Jeanne d'Arc, 21000 Dijon, France.ORCID 0000-0001-8499-7984
Naziha MarrakchiLaboratoire des Biomolécules, Venins et Applications Théranostiques (LR20IPT01), Institut Pasteur de Tunis, Université de Tunis El Manar, Tunis 1002, Tunisia.
Tunis University · TNInserm · FRInstitut Salah-Azaïz · TN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Snake venom proteins, which are responsible for deadly snakebite envenomation, induce severe injuries including neurotoxicity, myotoxicity, cardiotoxicity, hemorrhage, and the disruption of blood homeostasis. Yet, many snake-venom proteins have been developed as potential drugs for treating human diseases due to their pharmacological effects. In this study, we evaluated the use of, an L-amino acid oxidase isolated from

Indexed as

Alanine TransaminaseAnimalsCell Line, TumorCell SurvivalChick EmbryoCreatinineEdemaHemorrhageHumansL-Amino Acid OxidaseL-Lactate DehydrogenaseMaleMiceViperidaeViper VenomsAlanine TransaminaseCreatinineL-Amino Acid OxidaseL-Lactate DehydrogenaseViper Venomsapoptosisenvenomationglioblastoma cellsSV-LAAOstoxicity

Identifiers

PMID34941741
PMCPMC8704781
OpenAlexW4200132796

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.