Evidence map›Paper›PMID 34941698›Full record

ReviewToxins2021

Infant Botulism: Checklist for Timely Clinical Diagnosis and New Possible Risk Factors Originated from a Case Report and Literature Review.

Robertino Dilena, Mattia Pozzato, Lucia Baselli, Giovanna Chidini, Sergio Barbieri, Concetta Scalfaro, Guido Finazzi, Davide Lonati, Carlo Alessandro Locatelli, Alberto Cappellari and 1 more

Open access · goldAbstract readCase ReportsReview
In one paragraph

Review in Toxins, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Investigating the dual nature ofLe infezioni in medicina · 2026
    Review
  5. Article
  6. Review
  7. Review
  8. First case of infant botulism in Sicily-case report.Italian journal of pediatrics · 2024
    Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Robertino DilenaUnità di Neurofiopatologia, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.ORCID 0000-0003-1064-1840
Mattia PozzatoNeurology Unit & MS Centre, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.
Lucia BaselliPediatric Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.
Giovanna ChidiniPediatric Intensive Care Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.
Sergio BarbieriUnità di Neurofiopatologia, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.ORCID 0000-0001-9414-6307
Concetta ScalfaroNational Reference Centre for Botulism, Nutrition and Veterinary Public Health, Department of Food Safety, Istituto Superiore di Sanità, 00161 Rome, Italy.
Guido FinazziDepartment of Food Control, Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia-Romagna, 25124 Brescia, Italy.
Davide LonatiToxicology Unit, Laboratory of Clinical and Experimental Toxicology, and Poison Control Centre and National Toxicology Information Centre, Istituti Clinici Scientifici Maugeri IRCCS, 27100 Pavia, Italy.ORCID 0000-0001-6285-3445
Carlo Alessandro LocatelliToxicology Unit, Laboratory of Clinical and Experimental Toxicology, and Poison Control Centre and National Toxicology Information Centre, Istituti Clinici Scientifici Maugeri IRCCS, 27100 Pavia, Italy.ORCID 0000-0003-2154-5897
Alberto CappellariUnità di Neurofiopatologia, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.
Fabrizio AnniballiNational Reference Centre for Botulism, Nutrition and Veterinary Public Health, Department of Food Safety, Istituto Superiore di Sanità, 00161 Rome, Italy.ORCID 0000-0003-3273-9638
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITIstituti Clinici Scientifici Maugeri · ITIstituto Superiore di Sanità · ITIstituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna "Bruno Ubertini" · ITUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infant botulism is a rare and underdiagnosed disease caused by BoNT-producing clostridia that can temporarily colonize the intestinal lumen of infants less than one year of age. The diagnosis may be challenging because of its rareness, especially in patients showing atypical presentations or concomitant coinfections. In this paper, we report the first infant botulism case associated with Cytomegalovirus coinfection and transient hypogammaglobulinemia and discuss the meaning of these associations in terms of risk factors. Intending to help physicians perform the diagnosis, we also propose a practical clinical and diagnostic criteria checklist based on the revision of the literature.

Indexed as

AgammaglobulinemiaBotulismChecklistClostridium botulinumCoinfectionCytomegalovirusCytomegalovirus InfectionsHumansInfantMaleRisk Factorscytomegalovirusdiagnosisdiagnostic criteriahypogammaglobulinemiainfant botulismrisk factor

Identifiers

PMID34941698
PMCPMC8703831
OpenAlexW3216294241

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.