Evidence map›Paper›PMID 34941635›Full record

ArticlePharmacy (Basel, Switzerland)2021

Patterns and Predictors of Off-Label Drug Prescribing in Psychiatric Practice: A Qualitative Study.

Sadia Shakeel, Shagufta Nesar, Hina Rehman, Khizra Jamil, Imran Ahsan Mallick, Muhammad Shahid Mustafa, Mudassir Anwar, Shazia Jamshed

Open access · goldAbstract read
In one paragraph

Article in Pharmacy (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 3 countries.

Sadia ShakeelDepartment of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Dow College of Pharmacy, Dow University of Health Sciences, Karachi 74200, Pakistan.ORCID 0000-0003-4941-3124
Shagufta NesarJinnah College of Pharmacy, Sohail University, Karachi 74000, Pakistan.
Hina RehmanDepartment of Pharmacy Practice, Institute of Pharmaceutical Sciences, Jinnah Sind Medical University, Karachi 75510, Pakistan.
Khizra JamilDepartment of Psychology, University of Karachi, Karachi 75270, Pakistan.
Imran Ahsan MallickDepartment of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Dow College of Pharmacy, Dow University of Health Sciences, Karachi 74200, Pakistan.
Muhammad Shahid MustafaDiplomat American Board of Psychiatry and Neurology, Neuro Care Clinic, Karachi 75100, Pakistan.
Mudassir AnwarSchool of Pharmacy, University of Otago, Dunedin 9054, New Zealand.
Shazia JamshedDepartment of Clinical Pharmacy and Practice, Faculty of Pharmacy, Universiti Sultan Zainal Abidin, Kuala Terengganu 21300, Malaysia.ORCID 0000-0003-0773-0463
Dow University of Health Sciences · PKJinnah Sindh Medical University · PKSohail UniversitySultan Zainal Abidin University · MYUniversity of Karachi · PKUniversity of Otago · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Off-label drug prescribing (OLDP) must be based on strong scientific evidence to make sure that patients get the optimum therapeutic outcomes. Adherence to the prerequisites is determined by the physicians' attitude and knowledge. In this context, the present study was conducted with the goal of investigating psychiatrists' perceptions of the use of OLDP in their clinical practice. A total of 14 psychiatrists were interviewed using a semi-structured interview guide. Thematic content analysis was performed. Data saturation was achieved at the 12th interview. Six major themes and fifteen subthemes emerged from qualitative interviews. Among the major themes were knowledge and concepts about the off-label drugs, attitude and current practice of prescribing off-label drugs, and rationale of prescribing and suggestions for reducing the use of off-label drugs. Almost all of the respondents interviewed provided detailed comments concerning the OLDP concept, depicted an optimistic approach and deemed that OLDP is quite common in psychiatry. Off-label usage of benzodiazepines such as clonazepam, diazepam and lorazepam in mania, depression, and obsessive-compulsive disorder were commonly reported. It was observed that the majority of the respondents did not inform the patients before prescribing off-label drugs. The present findings revealed that respondents had awareness; however, they depicted diverse attitudes towards prescribing off-label drugs. Further education and sensitization in regions with impoverished knowledge would certainly assist in preventing the risks associated with the use of OLDP.

Indexed as

attitudeknowledgeoff-label drug prescribingPakistanpsychiatristsqualitative study

Identifiers

PMID34941635
PMCPMC8703660
OpenAlexW4200458854

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.