Evidence map›Paper›PMID 34941495›Full record

ArticleIEEE transactions on bio-medical engineering2022

Improving the Energy Cost of Incline Walking and Stair Ascent With Ankle Exoskeleton Assistance in Cerebral Palsy.

Ying Fang, Greg Orekhov, Zachary F Lerner

Abstract read
In one paragraph

Article in IEEE transactions on bio-medical engineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Ankle Exoskeleton Assistance Reduces Knee Contact Force During Walking in Individuals With Cerebral Palsy.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2026
    Article
  3. A Lightweight Powered Hip Exoskeleton With Parallel Actuation for Frontal and Sagittal Plane Assistance.IEEE transactions on robotics : a publication of the IEEE Robotics and Automation Society · 2025
    Article
  4. Article
  5. Review
  6. Article
  7. Walking on Real-world Terrain with an Ankle Exoskeleton in Cerebral Palsy.IEEE transactions on medical robotics and bionics · 2024
    Article
  8. Article
  9. Advances on mechanical designs for assistive ankle-foot orthoses.Frontiers in bioengineering and biotechnology · 2023
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ying Fang
Greg Orekhov
Zachary F Lerner

Funding

Augmenting Ankle Plantarflexor Function and Walking Capacity in Children with Cerebral PalsyR01HD107277 · NICHD · NORTHERN ARIZONA UNIVERSITY · PI LERNER, ZACHARY FOREST · 2021 to 2025
$2.1M
Development of a robotic ankle assist device to improve mobility in individuals with movement disorders.R44HD104328 · NICHD · BIOMOTUM, LLC · PI BROWNING, RAYMOND CLIFTON · 2020 to 2022
$2.0M
Wearable Ankle Assistance to Improve Walking Economy in Children with Cerebral PalsyR15HD099664 · NICHD · NORTHERN ARIZONA UNIVERSITY · PI LERNER, ZACHARY FOREST · 2019 to 2019
$424k
NICHD NIH HHS R01 HD107277NICHD NIH HHS R15 HD099664NICHD NIH HHS R44 HD104328
6 · The paper itself

Abstract

objectiveMany individuals with cerebral palsy (CP) experience gait deficits resulting in metabolically-inefficient ambulation that is exacerbated by graded walking terrains. The primary goal of this study was to clinically-validate the accuracy and efficacy of adaptive ankle exoskeleton assistance during steady-state incline walking and stair ascent in individuals with CP. Exploratory goals were to assess safety and feasibility of using adaptive ankle exoskeleton assistance in real-world mixed-terrain settings.

methodsWe used a novel battery-powered ankle exoskeleton to provide adaptive ankle plantar-flexor assistance during stance phase. Seven ambulatory individuals with CP completed the study.

resultsAdaptive controller accuracy was 85% for incline walking and 81% for stair-stepping relative to the biological ankle moment. Assistance improved energy cost of steady-state incline walking by 14% (p = 0.004) and stair ascent by 21% (p = 0.001) compared to walking without the device. Assistance reduced the muscular demand for the soleus and vastus lateralis during both activities. All participants were able to safely complete the real-world mixed-terrain route, with adaptive ankle assistance resulting in improved outcomes compared to walking with the device providing zero-torque; no group-level differences were found compared to walking without the device, yet individuals with more impairment exhibited a marked improvement.

conclusionAdaptive ankle exoskeleton assistance can improve the energy cost of steady-state incline walking and stair ascent in individuals with CP. SIGNIFICANCE: As the first study to demonstrate safety and performance benefits of ankle assistance on graded terrains in CP, these findings encourage further investigation in free-living settings.

Indexed as

Cerebral PalsyExoskeleton DeviceAnkleAnkle JointBiomechanical PhenomenaElectromyographyGaitHumansWalking

Identifiers

PMID34941495
PMCPMC9254331

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.