ArticleJournal of applied physiology (Bethesda, Md. : 1985)2022
The effect of local passive heating on skeletal muscle histamine concentration: implications for exercise-induced histamine release.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 11 citations in OpenAlex.
- Histamine is a molecular transducer of adaptation to endurance exercise training in humans.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Trial
- Histamine Intolerance Through a Functional Medicine Lens: A Systems-Based Review.Integrative medicine (Encinitas, Calif.) · 2026Article
- Heat Therapy: Targeting Health, Disease, and Disability.Comprehensive Physiology · 2026Review
- Article
- Muscle temperature increases during a single far infrared sauna session without changes in intestinal temperature.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Regulation of diel locomotor activity and retinal responses of Anopheles stephensi by ingested histamine and serotonin is temperature- and infection-dependent.PLoS pathogens · 2025Article
- Metabolic small talk during exercise: The role of metabokines and lipokines in interorgan signalling.Current opinion in endocrine and metabolic research · 2024Review
- Cyclooxygenase inhibition does not blunt thermal hyperemia in skeletal muscle of humans.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Heatstroke-induced acute kidney injury and the innate immune system.Frontiers in medicine · 2023Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Aerobic exercise induces mast cell degranulation and increases histamine formation by histidine decarboxylase, resulting in an ∼150% increase in intramuscular histamine. The purpose of this study was to determine if the increase in skeletal muscle temperature associated with exercise is sufficient to explain this histamine response. Specifically, we hypothesized that local passive heating that mimics the magnitude and time course of changes in skeletal muscle temperature observed during exercise would result in increased intramuscular histamine concentrations comparable to exercising values. Seven subjects participated in the main study in which pulsed short-wave diathermy was used to passively raise the temperature of the vastus lateralis over 60 min. Heating increased intramuscular temperature from 32.6°C [95% confidence interval (CI) 32.0°C to 33.2°C] to 38.9°C (38.7°C to 39.2°C) (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.