ArticleScience (New York, N.Y.)2021
Cell-by-cell dissection of phloem development links a maturation gradient to cell specialization.
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Article in Science (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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49citing papers in PubMed
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49 citing papers in PubMed.
- Integrative genetic and hormonal coordination of endocarp/stone development in drupe fruit.Horticulture research · 2026Review
- Phylogenomic analysis supports the deep and gradual evolution of water-conducting tissues.Plant physiology · 2026Article
- Benchmarking plant single cell RNA-sequencing sample processing strategies.The EMBO journal · 2026Article
- Selective degradation processes in plants are not limited to autophagy.Plant cell reports · 2026Review
- Single Cell Multiomics of Hooked Potato Stolons Reveals Parallels to Shoot Apical Meristems in Arabidopsis.Plant biotechnology journal · 2026Article
- Chemical Priming by Neonicotinoids Unveils CaNEN4 as a Susceptibility Gene Against Phytophthora capsici in Pepper.Molecular plant pathology · 2026Article
- Essential developmental processes in Physcomitrium patens require distinct levels of total activity provided by functionally redundant PpROP GTPases.The New phytologist · 2025Article
- The curious origins of a high-stress training technique mainlining: its molecular, biochemical, and agronomic perspectives for the cultivation of Cannabis sativa.Journal of cannabis research · 2025Review
- Iron deficiency changes regulatory mechanisms governing sieve element cell differentiation.Nature communications · 2025Article
- The ZAT14 family promotes cell death and regulates expansins to affect xylem formation and salt tolerance in Arabidopsis.The Plant cell · 2025Article
- DNA methylation in plant heterosis: mechanisms and prospects.Functional & integrative genomics · 2025Review
- Pectin Metabolism Influences Phloem Architecture and Flowering Time in Arabidopsis Thaliana.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- The impact of asymmetrical gene expression on the development of spike morphology iniMetaOmics · 2025Article
- Exploring the untapped potential of single-cell and spatial omics in plant biology.The New phytologist · 2025Review
- Developmental landscape and asymmetric gene expression in the leaf vasculature ofHorticulture research · 2025Article
- Identification of phloem-specific proteinaSEOus structure heterogeneity in sieve element of Populus trichocarpa.BMC plant biology · 2025Article
- Polarized subcellular activation of Rho proteins by specific ROPGEFs drives pollen germination in Arabidopsis thaliana.PLoS biology · 2025Article
- A space for time. Exploring temporal regulation of plant development across spatial scales.The Plant journal : for cell and molecular biology · 2025Review
- The dynamic and diverse nature of parenchyma cells in the Arabidopsis root during secondary growth.Nature plants · 2025Article
- Is autophagy always a death sentence? A case study of highly selective cytoplasmic degradation during phloemogenesis.Annals of botany · 2025Article
Corrections and comments
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Authors and funding
32 authors.
Pawel Roszak *The Sainsbury Laboratory, University of Cambridge, Cambridge, UK.ORCID 0000-0002-7822-494X
Jung-Ok Heo *The Sainsbury Laboratory, University of Cambridge, Cambridge, UK.ORCID 0000-0002-5088-6044
Bernhard Blob *The Sainsbury Laboratory, University of Cambridge, Cambridge, UK.ORCID 0000-0003-4269-7742
Koichi Toyokura *The Sainsbury Laboratory, University of Cambridge, Cambridge, UK.ORCID 0000-0001-7775-7886
Yuki Sugiyama *The Sainsbury Laboratory, University of Cambridge, Cambridge, UK.ORCID 0000-0002-5235-2943
Maria Angels de Luis Balaguer *Plant and Microbial Biology Department, North Carolina State University, Raleigh, NC, USA.
Winnie W Y Lau *Wellcome Trust and MRC Cambridge Stem Cell Institute and Department of Haematology, University of Cambridge, Cambridge, UK.ORCID 0000-0003-1209-1854
Fiona Hamey *Wellcome Trust and MRC Cambridge Stem Cell Institute and Department of Haematology, University of Cambridge, Cambridge, UK.ORCID 0000-0001-7299-2860
Jacopo Cirrone *Computer Science Department, Courant Institute for Mathematical Sciences, New York University, New York, NY, USA.
Ewelina MadejFaculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, Poland.ORCID 0000-0002-0729-0245
Alida M BouattaPlant Systems Biology, Technical University of Munich, Freising, Germany.ORCID 0000-0001-9326-7561
Xin WangInstitute of Biotechnology, HiLIFE/Organismal and Evolutionary Biology Research Programme, Faculty of Biological and Environmental Sciences, Viikki Plant Science Centre, University of Helsinki, Helsinki, Finland.
Marjorie GuichardInstitute of Cell and Interaction Biology, CEPLAS, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.ORCID 0000-0003-4417-3504
Robertas UrsacheThe Sainsbury Laboratory, University of Cambridge, Cambridge, UK.
Hugo TavaresThe Sainsbury Laboratory, University of Cambridge, Cambridge, UK.ORCID 0000-0001-9373-2726
Kevin VerstaenData Mining and Modelling for Biomedicine, VIB Center for Inflammation Research, Ghent, Belgium.ORCID 0000-0003-3582-0298
Jos WendrichDepartment of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, Belgium.ORCID 0000-0002-6198-3763
Charles W MelnykDepartment of Plant Biology, Swedish University of Agricultural Sciences, Uppsala, Sweden.ORCID 0000-0003-3251-800X
Yoshihisa OdaDepartment of Gene Function and Phenomics, National Institute of Genetics, Mishima, Japan.ORCID 0000-0001-6934-4424
Dennis ShashaComputer Science Department, Courant Institute for Mathematical Sciences, New York University, New York, NY, USA.ORCID 0000-0002-7036-3312
Sebastian E AhnertThe Sainsbury Laboratory, University of Cambridge, Cambridge, UK.ORCID 0000-0003-2613-0041
Yvan SaeysData Mining and Modelling for Biomedicine, VIB Center for Inflammation Research, Ghent, Belgium.ORCID 0000-0002-0415-1506
Bert De RybelDepartment of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, Belgium.ORCID 0000-0002-9551-042X
Renze HeidstraDepartment of Plant Sciences, Wageningen University and Research, Wageningen, Netherlands.ORCID 0000-0001-9032-5770
Ben ScheresDepartment of Plant Sciences, Wageningen University and Research, Wageningen, Netherlands.ORCID 0000-0001-5400-9578
Guido GrossmannInstitute of Cell and Interaction Biology, CEPLAS, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.ORCID 0000-0001-7529-9244
Ari Pekka MähönenInstitute of Biotechnology, HiLIFE/Organismal and Evolutionary Biology Research Programme, Faculty of Biological and Environmental Sciences, Viikki Plant Science Centre, University of Helsinki, Helsinki, Finland.ORCID 0000-0001-6051-866X
Philipp DenningerPlant Systems Biology, Technical University of Munich, Freising, Germany.ORCID 0000-0003-3794-2360
Berthold GöttgensWellcome Trust and MRC Cambridge Stem Cell Institute and Department of Haematology, University of Cambridge, Cambridge, UK.ORCID 0000-0001-6302-5705
Rosangela SozzaniPlant and Microbial Biology Department, North Carolina State University, Raleigh, NC, USA.ORCID 0000-0003-3316-2367
Kenneth D BirnbaumCenter for Genomics and Systems Biology, New York University, New York, NY, USA.ORCID 0000-0002-8423-6859
Yrjö HelariuttaThe Sainsbury Laboratory, University of Cambridge, Cambridge, UK.ORCID 0000-0002-7287-8459
Funding
Mapping the Trajectory of Cell Fate TransitionsR01GM078279 · NIGMS · NEW YORK UNIVERSITY · PI BIRNBAUM, KENNETH DAVID · 2006 to 2019
$4.2MRegeneration of Complex Patterns in PlantsR35GM136362 · NIGMS · NEW YORK UNIVERSITY · PI Kenneth David Birnbaum · 2020 to 2026
$3.1MBiotechnology and Biological Sciences Research Council BB/N013158/1European Research Council 714055Medical Research Council MC_PC_17230Medical Research Council MR/M008975/1NIGMS NIH HHS R01 GM078279NIGMS NIH HHS R35 GM136362Wellcome Trust
Abstract
In the plant meristem, tissue-wide maturation gradients are coordinated with specialized cell networks to establish various developmental phases required for indeterminate growth. Here, we used single-cell transcriptomics to reconstruct the protophloem developmental trajectory from the birth of cell progenitors to terminal differentiation in the
Indexed as
ArabidopsisArabidopsis ProteinsCell DifferentiationGTP-Binding ProteinsMeristemPhloemPlant RootsRNA-SeqSignal TransductionSingle-Cell AnalysisTranscription FactorsTranscriptomeAPL protein, ArabidopsisArabidopsis ProteinsAT2G37590 protein, ArabidopsisGTP-Binding ProteinsTranscription Factors
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