ArticleScience (New York, N.Y.)2021
Fibrin is a critical regulator of neutrophil effector function at the oral mucosal barrier.
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Article in Science (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers.
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120citing papers in PubMed
19.1field-weighted citation impact, top 1% of its field
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Who cites it
120 citing papers in PubMed, 176 citations in OpenAlex.
- Fibrinolysis Resistance After Injury Is a Risk Factor for a Hospital-Acquired Pneumonia-Like Disease Pattern.Surgical infections · 2024Trial
- Platelets mediate fibrin-induced thromboinflammation and NETosis through a GPVI-polyphosphate-FXIIa procoagulant axis.Blood vessels, thrombosis & hemostasis · 2026Article
- Circulating Nucleosomes are Elevated in Trauma Patients with Venous Thromboembolism: A Prospective Case-Cohort Study.Shock (Augusta, Ga.) · 2026Article
- Long-rod nano-hydroxyapatite derived G-LR-HA@TZ acts as a multifunctional regenerative tool for periodontal bone.Bioactive materials · 2026Article
- Macrophages Intracellularly Gelated With Bioactive Hydrogels for Synergistic Neutralization, Eradication, and Osteopromotion in Periodontitis Treatment.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Attenuating the pathological cycle of periodontitis: CGL NPs suppress pathological mineralization and modulate the periodontal microenvironment.Materials today. Bio · 2026Article
- ZNF750 suppresses esophageal squamous cell carcinoma by maintaining epithelial barrier-driven mucosal immune homeostasis.Biology direct · 2026Article
- Integrated transcriptomic and metabolomic analysis to elucidate key genes and signaling pathways involved in the promotion of periodontitis by hypertension.Scientific reports · 2026Article
- Structural immunity: immune cells as architects of tissue barriers.Nature reviews. Immunology · 2026Review
- Bioinspired lipid droplets nanoplatform for periodontitis therapy: Integrated antibacterial, mitochondrial repair, and immunomodulatory functions.Materials today. Bio · 2026Article
- Designing adhesive hydrogels for oral diseases treatment.Materials today. Bio · 2026Review
- Mucosal Inflammation Shapes Human Neutrophil States in Tissue and Circulation.bioRxiv : the preprint server for biology · 2026Article
- Association and predictive value of C-reactive protein, fibrinogen and periodontal indices in periodontitis severity : a cross-sectional study.Clinical oral investigations · 2026Article
- Integrated Genome-wide Association and Single-cell Transcriptomic Analysis Identifies OAT as Therapeutic Targets for Periodontitis.Inflammation · 2026Article
- Human gingival fibroblast-mediated remodeling of three-dimensional fibrin hydrogels.Matrix biology plus · 2026Article
- Cascade Therapy of Periodontitis via Sequential Release of Ribosome-Targeting Antimicrobial Peptide and Irisin From a Multifunctional MOF-Based System.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Nucleoside-Based Hydrogel Platform Synergizes with Photothermal Effects for Enhanced Biofilm Eradication Against Periodontitis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Genome-wide association study of periodontitis severity and progression.Journal of periodontology · 2026Article
- Emerging potential of engineered nanozymes in periodontitis treatment: from monotherapy to hierarchical therapy.Journal of nanobiotechnology · 2026Review
- Fibrinogen was associated with subgingival microbiome in periodontal diseases: a pilot study.Journal of oral microbiology · 2026Article
60 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
24 authors at 6 institutions in 3 countries.
Lakmali M SilvaProteases and Tissue Remodeling Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-6282-2657
Andrew D DoyleNIDCR Imaging Core, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-0442-5415
Teresa Greenwell-WildOral Immunity and Inflammation Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
Nicolas DutzanOral Immunity and Inflammation Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-8343-0214
Collin L TranProteases and Tissue Remodeling Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-7407-1571
Loreto AbuslemeOral Immunity and Inflammation Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-7210-1236
Lih Jiin JuangMichael Smith Laboratories and Department of Biochemistry and Molecular Biology, The University of British Columbia, Vancouver, BC, Canada.
Jerry LeungMichael Smith Laboratories and Department of Biochemistry and Molecular Biology, The University of British Columbia, Vancouver, BC, Canada.
Elizabeth M ChunProteases and Tissue Remodeling Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
Andrew G LumOral Immunity and Inflammation Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
Cary S AglerDivision of Oral and Craniofacial Health Sciences, Adams School of Dentistry, University of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0002-5510-7214
Carlos E ZuazoOral Immunity and Inflammation Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
Megan SibreeProteases and Tissue Remodeling Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-8443-7311
Priyam JaniMolecular Biology of Bones and Teeth Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-7768-7865
Vardit KramMolecular Biology of Bones and Teeth Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
Daniel MartinNIDCR Genomics and Computational Biology Core, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-8880-9087
Kevin MossDivision of Oral and Craniofacial Health Sciences, Adams School of Dentistry, University of North Carolina, Chapel Hill, NC, USA.
Michail S LionakisFungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-4994-9500
Francis J CastellinoWM Keck Center for Transgene Research, University of Notre Dame, Notre Dame, IN, USA.ORCID 0000-0003-0317-9539
Christian J KastrupMichael Smith Laboratories and Department of Biochemistry and Molecular Biology, The University of British Columbia, Vancouver, BC, Canada.
Matthew J FlickDepartment of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0002-5034-3162
Kimon DivarisDivision of Pediatric and Public Health, Adams School of Dentistry, University of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0003-1290-7251
Thomas H BuggeProteases and Tissue Remodeling Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-7046-4060
Niki M MoutsopoulosOral Immunity and Inflammation Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-7365-6735
National Institutes of Health · USUniversity of North Carolina at Chapel Hill · USNational Institute of Dental and Craniofacial Research · USCanada's Michael Smith Genome Sciences Centre · CAMedical College of Wisconsin · USUniversity of Notre Dame · US
Funding
NIDCR DIR Scientific Cores (Combined Technical Research Core)ZICDE000729 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI ABSHARI, MEHRNOOSH · 2009 to 2025
$31.7MGenomic and Computational Biology Support for NIDCD Intramural ResearchZICDC000086 · NIDCD · NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS · PI MORELL, ROBERT J · 2015 to 2025
$19.8MNIDCR Annual Reports - Veterinary Resources CoreZIGDE000740 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI DAVIDSON, LAUREN · 2012 to 2025
$11.7MGenome-Wide Association Study of Early Childhood CariesU01DE025046 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DIVARIS, KIMON · 2015 to 2019
$8.4MSTRUCTURE-FUNCTION STUDIES ON PLASMINOGEN AND PLASMINR01HL013423 · NHLBI · UNIVERSITY OF NOTRE DAME · PI CASTELLINO, FRANCIS J, LEE, SHAUN · 1985 to 2021
$7.9MThrombin-dependent mechanisms of pancreatic ductal adenocarcinoma diseaseR01CA211098 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FLICK, MATTHEW J. · 2017 to 2022
$2.2MFibrin(ogen) control of metabolic inflammation and obesityR01DK112778 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FLICK, MATTHEW J. · 2019 to 2022
$1.5MFibrin-neutrophil interaction in periodontitis immunopathologyR00DE030124 · NIDCR · HARVARD MEDICAL SCHOOL · PI SILVA, MUNASINGHAGE LAKMALI · 2023 to 2025
$728kIntramural NIH HHS ZIC DC000086Intramural NIH HHS ZIC DE000729Intramural NIH HHS ZIG DE000740NCI NIH HHS R01 CA211098NHLBI NIH HHS R01 HL013423NIDCR NIH HHS R00 DE030124NIDCR NIH HHS U01 DE025046NIDDK NIH HHS R01 DK112778
Abstract
Tissue-specific cues are critical for homeostasis at mucosal barriers. Here, we report that the clotting factor fibrin is a critical regulator of neutrophil function at the oral mucosal barrier. We demonstrate that commensal microbiota trigger extravascular fibrin deposition in the oral mucosa. Fibrin engages neutrophils through the α
Indexed as
Neutrophil ActivationAlveolar Bone LossAnimalsExtracellular TrapsFemaleFibrinFibrinogenFibrinolysinFibrinolysisGastrointestinal MicrobiomeGingivaHumansImmunity, MucosalMacrophage-1 AntigenMaleMiceFibrinFibrinogenFibrinolysinMacrophage-1 AntigenPlasminogenReactive Oxygen Species
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.