Evidence map›Paper›PMID 34940704›Full record

ArticleMarine drugs2021

The 3/4- and 3/6-Subfamily Variants of α-Conotoxins GI and MI Exhibit Potent Inhibitory Activity against Muscular Nicotinic Acetylcholine Receptors.

Xiaoli Ma, Qiuyuan Huang, Shuo Yu, Shujing Xu, Yue Huang, Zhiming Zhao, Xinrong Xiao, Qiuyun Dai

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Marine drugs, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Xiaoli MaBeijing Institute of Biotechnology, Beijing 100071, China.
Qiuyuan HuangBeijing Institute of Biotechnology, Beijing 100071, China.
Shuo YuBeijing Institute of Biotechnology, Beijing 100071, China.
Shujing XuBeijing Institute of Biotechnology, Beijing 100071, China.
Yue HuangBeijing Institute of Biotechnology, Beijing 100071, China.
Zhiming ZhaoBeijing Institute of Biotechnology, Beijing 100071, China.
Xinrong XiaoInstitute of Chemistry and Chemical Engineering, University of South China, Henyang 421000, China.
Qiuyun DaiBeijing Institute of Biotechnology, Beijing 100071, China.
Institute of Chemistry · CNUniversity of South China · CN

Funding

Ministry of Science and Technology 2019YFC0312605
6 · The paper itself

Abstract

α-Conotoxins GI and MI belong to the 3/5 subfamily of α-conotoxins and potently inhibit muscular nicotinic acetylcholine receptors (nAChRs). To date, no 3/4- or 3/6-subfamily α-conotoxins have been reported to inhibit muscular nAChRs. In the present study, a series of new 3/4-, 3/6-, and 3/7-subfamily GI and MI variants were synthesized and functionally characterized by modifications of loop2. The results show that the 3/4-subfamily GI variant GI[∆8G]-II and the 3/6-subfamily variants GI[+13A], GI[+13R], and GI[+13K] displayed potent inhibition of muscular nAChRs expressed in

Indexed as

Conus SnailAnimalsAnimals, Outbred StrainsAquatic OrganismsConotoxinsFemaleInhibitory Concentration 50MaleMiceNicotinic AntagonistsOocytesRatsReceptors, NicotinicStructure-Activity RelationshipXenopus laevisConotoxinsNicotinic AntagonistsReceptors, Nicotinicmuscular nicotinic acetylcholine receptorsstructure–activity relationshipsubfamily variantsα-conotoxins GI and MI

Identifiers

PMID34940704
PMCPMC8704989
OpenAlexW4200211086

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.