Evidence map›Paper›PMID 34940571›Full record

ReviewMetabolites2021

Effect of Exercise on Brain Health: The Potential Role of Lactate as a Myokine.

Takeshi Hashimoto, Hayato Tsukamoto, Soichi Ando, Shigehiko Ogoh

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Metabolites, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 2 pooled it
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 2 syntheses or guidelines pooled it, 90 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Takeshi HashimotoFaculty of Sport and Health Science, Ritsumeikan University, Osaka 525-8577, Japan.ORCID 0000-0003-3951-5290
Hayato TsukamotoFaculty of Sport and Health Science, Ritsumeikan University, Osaka 525-8577, Japan.ORCID 0000-0001-5512-0497
Soichi AndoGraduate School of Informatics and Engineering, The University of Electro-Communications, Tokyo 182-8585, Japan.
Shigehiko OgohDepartment of Biomedical Engineering, Toyo University, Saitama 350-8585, Japan.ORCID 0000-0001-5297-6468
Ritsumeikan University · JPToyo University · JPUniversity of Electro-Communications · JP

Funding

Grant-in-Aid for Scientific Research from the Japanese Ministry of Education, Culture, Sports, Science, and Technology 20K21774Grant-in-Aid for Scientific Research from the Japanese Ministry of Education, Culture, Sports, Science, and Technology 21H03384
6 · The paper itself

Abstract

It has been well established in epidemiological studies and randomized controlled trials that habitual exercise is beneficial for brain health, such as cognition and mental health. Generally, it may be reasonable to say that the physiological benefits of acute exercise can prevent brain disorders in late life if such exercise is habitually/chronically conducted. However, the mechanisms of improvement in brain function via chronic exercise remain incompletely understood because such mechanisms are assumed to be multifactorial, such as the adaptation of repeated acute exercise. This review postulates that cerebral metabolism may be an important physiological factor that determines brain function. Among metabolites, the provision of lactate to meet elevated neural activity and regulate the cerebrovascular system and redox states in response to exercise may be responsible for exercise-enhanced brain health. Here, we summarize the current knowledge regarding the influence of exercise on brain health, particularly cognitive performance, with the underlying mechanisms by means of lactate. Regarding the influence of chronic exercise on brain function, the relevance of exercise intensity and modality, particularly high-intensity interval exercise, is acknowledged to induce "metabolic myokine" (i.e., lactate) for brain health.

Indexed as

angiogenesisbrain-derived neurotrophic factorcerebral blood flowexecutive functioninsulin-like growth factor-1mental healthneurogenesisnicotinamide adenine dinucleotide hydratevascular endothelial growth factor

Identifiers

PMID34940571
PMCPMC8709217
OpenAlexW3215537732

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.