ReviewMetabolites2021
Pesticides and Male Fertility: A Dangerous Crosstalk.
Review in Metabolites, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 65 citations in OpenAlex.
- Mapping the Global Evidence on Environmental and Climatic Factors Linked to Human Fertility-Related Outcomes: Protocol for a Scoping Review.JMIR research protocols · 2026Article
- Effects of quercetin in male rats' testis after consumption of permethrin: a transmission electron microscopy (TEM) study.Scientific reports · 2026Article
- Article
- Understanding the Secular Decline in Testosterone: Mechanisms, Consequences, and Clinical Perspectives.International journal of molecular sciences · 2026Review
- Effect of environmental contamination on male and female gametes.The Journal of reproduction and development · 2026Review
- Environmental determinants of male infertility: emerging threats and technological interventions.Frontiers in medicine · 2026Review
- Tributyltin chloride alters the structural, genomic, and epigenomic integrity of postejaculatory mammalian sperm.Epigenetics · 2025Article
- In vitro models of the male reproductive system: applications for developmental and reproductive toxicology.Toxicological sciences : an official journal of the Society of Toxicology · 2025Review
- Propiconazole-Induced Testis Damage and MAPK-Mediated Apoptosis and Autophagy in Germ Cells.Cells · 2025Article
- The Analysis and Risk Assessment of Organic Pollutants in Food Products.Foods (Basel, Switzerland) · 2025Article
- Insecticides and testicular health: mechanisms of injury and protective natural products.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Human sperm as an in vitro toxicity model: a versatile tool for assessing the risk of environmental contaminants.Archives of toxicology · 2025Article
- Chlorantraniliprole (Coragen® 20% SC) exposure induced reproductive toxicity mediated by oxidative stress, apoptosis, and sperm quality deficient in male Wistar rats.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Endocrine-disrupting pesticide exposure relevant to reproductive health: a case study from Costa Rica.Environmental monitoring and assessment · 2025Review
- Oxidative and Molecular-Structural Alterations of Spermatozoa in Swine and Ram Exposed to the Triazole Ipconazole.Toxics · 2025Article
- Sperm epigenetics and sperm RNAs as drivers of male infertility: truth or myth?Molecular and cellular biochemistry · 2025Review
- Do Lifestyle Interventions Mitigate the Oxidative Damage and Inflammation Induced by Obesity in the Testis?Antioxidants (Basel, Switzerland) · 2025Review
- Pesticides and public health: discussing risks in Brazilian agro-industrial growth.Frontiers in toxicology · 2025Article
- Article
- Signatures of metabolic diseases on spermatogenesis and testicular metabolism.Nature reviews. Urology · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
In recent decades, an increasing incidence of male infertility has been reported. Interestingly, and considering that pesticides have been used for a long time, the high incidence of this pathological state is concomitant with the increasing use of these chemicals, suggesting they are contributors for the development of human infertility. Data from literature highlight the ability of certain pesticides and/or their metabolites to persist in the environment for long periods of time, as well as to bioaccumulate in the food chain, thus contributing for their chronic exposure. Furthermore, pesticides can act as endocrine disrupting chemicals (EDCs), interfering with the normal function of natural hormones (which are responsible for the regulation of the reproductive system), or even as obesogens, promoting obesity and associated comorbidities, like infertility. Several in vitro and in vivo studies have focused on the effects and possible mechanisms of action of these pesticides on the male reproductive system that cause sundry negative effects, even though through diverse mechanisms, but all may lead to infertility. In this review, we present an up-to-date overview and discussion of the effects, and the metabolic and molecular features of pesticides on somatic cells and germinal tissues that affect germ cell differentiation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.