Evidence map›Paper›PMID 34940413›Full record

ReviewMembranes2021

Synthetic Cell as a Platform for Understanding Membrane-Membrane Interactions.

Bineet Sharma, Hossein Moghimianavval, Sung-Won Hwang, Allen P Liu

Abstract readReview
In one paragraph

Review in Membranes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Orchestrating Self-Replication in Artificial Cells with Digital Microfluidics.Small (Weinheim an der Bergstrasse, Germany) · 2025
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Engineering Functional Membrane-Membrane Interfaces by InterSpy.Small (Weinheim an der Bergstrasse, Germany) · 2023
    Article
  12. Methods to mechanically perturb and characterize GUV-based minimal cell models.Computational and structural biotechnology journal · 2023
    Review
  13. Article
  14. Biochemistry · 2022
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Bineet SharmaDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0001-5227-8096
Hossein MoghimianavvalDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Sung-Won HwangDepartment of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Allen P LiuDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-0309-7018

Funding

Development of a mechanosensitive synthetic cell for mediating intercellular communication - Diversity SupplementR01EB030031 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LIU, ALLEN PO-CHIH · 2020 to 2024
$1.3M
National Science Foundation 1935265NIH HHS R01 EB030031
6 · The paper itself

Abstract

In the pursuit of understanding life, model membranes made of phospholipids were envisaged decades ago as a platform for the bottom-up study of biological processes. Micron-sized lipid vesicles have gained great acceptance as their bilayer membrane resembles the natural cell membrane. Important biological events involving membranes, such as membrane protein insertion, membrane fusion, and intercellular communication, will be highlighted in this review with recent research updates. We will first review different lipid bilayer platforms used for incorporation of integral membrane proteins and challenges associated with their functional reconstitution. We next discuss different methods for reconstitution of membrane fusion and compare their fusion efficiency. Lastly, we will highlight the importance and challenges of intercellular communication between synthetic cells and synthetic cells-to-natural cells. We will summarize the review by highlighting the challenges and opportunities associated with studying membrane-membrane interactions and possible future research directions.

Indexed as

lipid bilayer membranemembrane fusionmembrane proteinssynthetic cell communicationssynthetic cells

Identifiers

PMID34940413
PMCPMC8706075

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.