Evidence map›Paper›PMID 34940290›Full record

ArticleMedicines (Basel, Switzerland)2021

Cytotoxic Tumour-Selective 1,5-Diaryl-3-Oxo-1,4-Pentadienes Mounted on a Piperidine Ring.

Praveen K Roayapalley, Hiroshi Sakagami, Keitaro Satoh, Shigeru Amano, Kenjiro Bandow, Renato J Aguilera, Karla G Cano Hernandez, Austre Y Schiaffino Bustamante, Stephen G Dimmock, Rajendra K Sharma and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medicines (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Synthetic Cyclic CAntioxidants (Basel, Switzerland) · 2025
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 4 countries.

Praveen K RoayapalleyDrug Discovery and Development Research Group, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.ORCID 0000-0003-3712-5790
Hiroshi SakagamiSchool of Dentistry, Meikai University, Sakado, Saitama 350-0283, Japan.ORCID 0000-0001-8001-2121
Keitaro SatohSchool of Dentistry, Meikai University, Sakado, Saitama 350-0283, Japan.
Shigeru AmanoSchool of Dentistry, Meikai University, Sakado, Saitama 350-0283, Japan.
Kenjiro BandowSchool of Dentistry, Meikai University, Sakado, Saitama 350-0283, Japan.ORCID 0000-0002-1362-3034
Renato J AguileraDepartment of Biological Sciences and Border Biomedical Research Center, The University of Texas at El Paso, El Paso, TX 79968-0519, USA.
Karla G Cano HernandezDepartment of Biological Sciences and Border Biomedical Research Center, The University of Texas at El Paso, El Paso, TX 79968-0519, USA.
Austre Y Schiaffino BustamanteDepartment of Biological Sciences and Border Biomedical Research Center, The University of Texas at El Paso, El Paso, TX 79968-0519, USA.
Stephen G DimmockDepartment of Finance, National University of Singapore, Singapore 119245, Singapore.
Rajendra K SharmaDepartment of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 0W8, Canada.
Umashankar DasDrug Discovery and Development Research Group, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.
Jonathan R DimmockDrug Discovery and Development Research Group, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.
Meikai University · JPUniversity of Saskatchewan · CAThe University of Texas at El Paso · USNational University of Singapore · SG

Funding

NIH-MARC T34GM008048-35
6 · The paper itself

Abstract

A series of 3,5-bis(benzylidene)-4-piperidones

Indexed as

4-piperidonescell cycle inhibitioncytotoxicityquantitative structure-activity relationships (QSAR)unsaturated ketonesWestern blot

Identifiers

PMID34940290
PMCPMC8707244
OpenAlexW4200291374

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.