Evidence map›Paper›PMID 34940133›Full record

ArticleCurrent issues in molecular biology2021

Case Report: Genetic Alterations Associated with the Progression of Carotid Paraganglioma.

Vladislav Pavlov, Anastasiya Snezhkina, Dmitry Kalinin, Alexander Golovyuk, Anastasiya Kobelyatskaya, Ildar Bakhtogarimov, Nadezhda Volchenko, George Krasnov, Anna Kudryavtseva

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Current issues in molecular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Non-Susceptibility Gene Variants in Head and Neck Paragangliomas.International journal of molecular sciences · 2024
    Article
  3. Intratumoral Microbiome in Head and Neck Paragangliomas.International journal of molecular sciences · 2024
    Article
  4. Comprehensive Genetic Study of Malignant Cervical Paraganglioma.International journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Vladislav PavlovEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.ORCID 0000-0002-2942-6393
Anastasiya SnezhkinaEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.ORCID 0000-0002-4421-4364
Dmitry KalininVishnevsky Institute of Surgery, Ministry of Health of the Russian Federation, 117997 Moscow, Russia.
Alexander GolovyukVishnevsky Institute of Surgery, Ministry of Health of the Russian Federation, 117997 Moscow, Russia.ORCID 0000-0001-6830-7832
Anastasiya KobelyatskayaEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Ildar BakhtogarimovEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Nadezhda VolchenkoNational Medical Research Radiological Center, Ministry of Health of the Russian Federation, 125284 Moscow, Russia.
George KrasnovEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Anna KudryavtsevaEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.ORCID 0000-0002-3722-8207
Engelhardt Institute of Molecular Biology · RUMinistry of Health of the Russian Federation · RU

Funding

Russian Science Foundation 21-14-00353
6 · The paper itself

Abstract

Paragangliomas (PGLs) are rare neuroendocrine tumors that can develop from any paraganglion across the body. The carotid body is the most often location of PGLs in the head and neck region. Carotid PGLs (CPGLs) are characterized by predominantly non-aggressive behavior; however, all tumors have the potential to metastasize. To date, molecular mechanisms of paraganglioma progression remain elusive. We report a case of a 38-year-old woman with metastatic CPGL manifesting as a recurrent tumor with lymph node metastasis. The tumor was fast-growing and had a high Ki-67 proliferation index. Immunohistochemical (IHC) examination and whole-exome sequencing were performed for both recurrent tumor and metastasis. A germline pathogenic splice acceptor variant in the

Indexed as

Genetic Association StudiesGenetic Predisposition to DiseaseGenetic VariationAdultBiomarkers, TumorCarotid BodyDisease ProgressionDNA Mutational AnalysisFemaleGenetic TestingHumansImmunohistochemistryMutationParagangliomaSuccinate DehydrogenaseBiomarkers, TumorSDHD protein, humanSuccinate Dehydrogenasecarotid paragangliomacase reportmetastasisrecurrent tumorSDHBTERTwhole-exome sequencing

Identifiers

PMID34940133
PMCPMC8928979
OpenAlexW4200171174

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.