Evidence map›Paper›PMID 34940077›Full record

ArticleCurrent oncology (Toronto, Ont.)2021

The Role of Farnesoid X Receptor in Accelerated Liver Regeneration in Rats Subjected to ALPPS.

Noemi Daradics, Pim B Olthof, Andras Budai, Michal Heger, Thomas M van Gulik, Andras Fulop, Attila Szijarto

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current oncology (Toronto, Ont.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Noemi DaradicsHepato-Pancreatico-Biliary (HPB) Surgical Research Center Hungary, Department of Surgery, Transplantation and Interventional Gastroenterology, Semmelweis University, 1082 Budapest, Hungary.ORCID 0000-0001-6918-7406
Pim B OlthofErasmus Medical Center, Department of Surgery, 3015 GD Rotterdam, The Netherlands.
Andras Budai2nd Department of Pathology, Semmelweis University, 1091 Budapest, Hungary.
Michal HegerJiaxing Key Laboratory for Photonanomedicine and Experimental Therapeutics, Department of Pharmaceutics, College of Medicine, Jiaxing University, Jiaxing 314001, China.ORCID 0000-0002-0630-4465
Thomas M van GulikDepartment of Surgery, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands.
Andras FulopHepato-Pancreatico-Biliary (HPB) Surgical Research Center Hungary, Department of Surgery, Transplantation and Interventional Gastroenterology, Semmelweis University, 1082 Budapest, Hungary.
Attila SzijartoHepato-Pancreatico-Biliary (HPB) Surgical Research Center Hungary, Department of Surgery, Transplantation and Interventional Gastroenterology, Semmelweis University, 1082 Budapest, Hungary.
Semmelweis University · HUAmsterdam UMC Location University of Amsterdam · NLErasmus MC · NLJiaxing University · CN

Funding

Bolyai János Research Grant of the Hungarian Academy of SciencesDutch Cancer Foundation KWF project # 10666European Society of Surgical Researchgrant for the establishment of the Jiaxing Key Laboratory for Photonanomedicine and Experimental TherapeuticsNew National Excellence Program of the Ministry of Human Capacities of Hungary ÚNKP-20-3-I-SE-9; NDSemmelweis University 250+ PhD Excellence Grant EFOP-3.6.3-VEKOP-16-2017 00009Zhejiang Provincial Foreign Expert Program Grant, Zhejiang Provincial Key Natural Science Foundation of China #Z20H160031
6 · The paper itself

Abstract

backgroundthe role of bile acid (BA)-induced farnesoid X receptor (Fxr) signaling in liver regeneration following associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) was investigated in a rat model.

methodsMale Wistar rats underwent portal vein ligation (PVL) (

resultsALLPS induced more extensive liver regeneration (

conclusionOur study elaborates on a possible linkage between BA-induced Fxr signaling and accelerated liver regeneration induced by ALPPS in rats. ALPPS could trigger liver regeneration via intestinal Fxr signaling cascades instead of hepatic Fxr signaling, thereby deviating from the mechanism of BA-mediated regeneration following one-stage hepatectomy.

Indexed as

HepatectomyLiver RegenerationAnimalsHumansLiverMalePortal VeinRatsRats, WistarALPPSbile acidFxrin vivo researchliver regenerationsurgical oncology

Identifiers

PMID34940077
PMCPMC8700148
OpenAlexW4200440855

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.