Observational studyJournal of hypertension2022
The association of uric acid with mortality modifies at old age: data from the uric acid right for heart health (URRAH) study.
Observational study in Journal of hypertension, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- Mediating Effect of Serum Uric Acid in the Association Between Nocturia and Mortality.International neurourology journal · 2025Article
- Serum uric acid and the risk of major adverse cardiovascular events and death among older adults: a population-based prospective cohort study.BMC geriatrics · 2025Article
- Higher serum uric acid levels and risk of all-cause mortality in general population: a systematic review and meta-analysis.Metabolism open · 2025Article
- Current updates and future perspectives in uric acid research, 2024.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Review
- Gout and Hyperuricemia: A Narrative Review of Their Comorbidities and Clinical Implications.Journal of clinical medicine · 2024Review
- Elevated blood pressure and hyperuricemia risk: a retrospective cohort study from Wuhu, China.Scientific reports · 2024Article
- Expert consensus for the diagnosis and treatment of patients with hyperuricemia and high cardiovascular risk: 2023 update.Cardiology journal · 2024Article
- A Cohort Study on the Correlation Between Serum Uric Acid Trajectory and New-Onset Hypertension Based on Longitudinal Health Examination Data in Henan Area.Journal of inflammation research · 2024Article
- The association of perioperative serum uric acid variation with in-hospital adverse outcomes in coronary artery bypass grafting patients.Frontiers in cardiovascular medicine · 2024Article
- The Results of the URRAH (Uric Acid Right for Heart Health) Project: A Focus on Hyperuricemia in Relation to Cardiovascular and Kidney Disease and its Role in Metabolic Dysregulation.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2023Review
- Association of hyperuricemia combined with sarcopenia on ASCVD risk.BMC cardiovascular disorders · 2023Article
- Serum Uric Acid Levels Are Associated with the Echogenic Features of Carotid Plaque Vulnerability in Elderly Patients with Atherosclerotic Disease.Metabolites · 2023Article
- Hyperuricaemia: prevalence and association with mortality in an elderly Finnish population.BMJ open · 2023Article
- Article
- Gender-Specific and U-Shaped Relationship Between Serum Uric Acid and All-Cause Mortality Among Chinese Older Adults: A National Population-Based Longitudinal Study.International journal of public health · 2023Article
- Association between the Weight-Adjusted Waist Index and Serum Uric Acid: A Cross-Sectional Study.International journal of clinical practice · 2023Article
- Correlation Analysis between Uric Acid and Metabolic Syndrome in the Chinese Elderly Population: A Cross-Sectional Study.International journal of endocrinology · 2023Article
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Authors and funding
42 authors at 19 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesIn older individuals, the role of serum uric acid (SUA) as risk factor for mortality is debated. This study investigated the association of SUA with all-cause and cardiovascular (CV) mortality in older adults participating in the large multicentre observational uric acid right for heart health (URRAH) study.
methodsEight thousand URRAH participants aged 65+ were included in the analysis. The predictive role of SUA was assessed using Cox regression models stratified according to the cut-off age of 75. SUA was tested as continuous and categorical variable (age-specific quartiles). The prognostic threshold of SUA for mortality was analysed using receiver operating characteristic curves.
resultsAmong participants aged 65-74, multivariate Cox regression analysis adjusted for CV risk factors and comorbidities identified an independent association of SUA with both all-cause mortality (hazard ratio [HR] 1.169, 95% confidence interval [CI] 1.107-1.235) and CV mortality (HR 1.146, 95% CI 1.064-1.235). The cut-off value of 4.8 mg/dl discriminated mortality status. In participants aged 75+, we observed a J-shaped relationship of SUA with all-cause and CV mortality, with risk increasing at extreme SUA levels.
conclusionsThese results confirmed the predictive role of SUA for all-cause and CV mortality in older adults, while revealing considerable age-related differences. Mortality risk increased at higher SUA levels in participants aged 65-74, with a prognostic threshold of 4.8 mg/dl. The relationship between SUA and mortality was J-shaped in oldest participants. Large interventional studies are needed to clarify the benefits and possible risks of urate-lowering treatments in older adults.
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